Medication issues
Dear Pharmacist,
I have been taking medication for hypertension, including 10 mg of Bacten film-coated tablets, 5 mg of Anpress stable tablets, and 160 mg of Felodipine film-coated tablets.
Three years ago, I added 10 mg of Valsartan film-coated tablets.
In October of last year, I experienced chest pain and discomfort under my ribs, along with chest tightness.
I visited Chang Gung Memorial Hospital to see a cardiologist, where I underwent a stress electrocardiogram and an echocardiogram.
When reviewing the results, the doctor mentioned that I might have a myocardial infarction and suggested that I pay out of pocket for further tests.
I told him that it was a bit difficult for me financially, so I took the report to my local clinic, which also has a cardiologist.
After reviewing the report, he prescribed an additional medication, 60 mg of Tien-Chuan Ai-Pi pulse sustained-release film-coated tablets, to be taken alongside my hypertension medications.
Yesterday, after taking a shower, I experienced heart pain again, which was quite distressing.
I coughed forcefully a few times, which helped a bit, but I still feel chest tightness in my heart and ribs.
This morning, I went to the clinic to explain my symptoms to the doctor, who prescribed another medication, 5 mg of Tien-Chuan Li-Xia tablets, to be taken once in the morning and once in the evening.
I also take a sleep medication every night before bed, which is 0.5 mg of Lopinavir tablets, along with 500 mg of calcium carbonate tablets.
I would like to ask the pharmacist about the potential side effects of taking so many medications in one day.
Are there any adverse reactions I should be aware of? Specifically, what are the side effects of the 5 mg Tien-Chuan Li-Xia tablets, and can they be taken together with my other medications as instructed for morning and evening doses?
Additionally, I frequently experience pain under my ribs and chest tightness, and I find it easy to become short of breath after exercising.
Thank you.
Cai Xiansheng, 30~39 year old female. Ask Date: 2016/03/20
Dr. Hou Fangmin reply Pharmacology
Hello:
1.
Betaloc (Metoprolol) 10 mg: A highly selective β-1 adrenergic receptor blocker with no intrinsic sympathomimetic activity (ISA) and no membrane-stabilizing effects.
It reduces heart rate and inhibits plasma renin activity.
It is used to alleviate or reduce symptoms of angina pectoris.
Side effects of Betaloc include fatigue, dizziness, and mild headache.
2.
Amlodipine 5 mg: It is recommended to take this medication with food or milk.
Avoid consuming grapefruit or grapefruit juice one hour before and two hours after taking this medication.
3.
Lercanidipine 160 mg: Indication: Hypertension.
Side effects: Headache (occurs in a small percentage of individuals).
4.
Fenofibrate 10 mg: Indications: Hypercholesterolemia, hypertriglyceridemia.
Fenofibrate is used to reduce the risk of myocardial infarction, lower the risk of stroke, and decrease the incidence of cardiovascular events in high-risk coronary heart disease populations.
5.
Tenormin (Atenolol) 60 mg: Indication: Prevention of angina attacks.
6.
Clonazepam 0.5 mg: This medication has multiple uses, including aiding sleep and alleviating anxiety.
Do not consume alcohol while taking this medication.
7.
Nicorandil: An antianginal agent with pharmacological synergistic effects and myocardial protective properties.
Side effects primarily include headache (3.60%), with others such as nausea, vomiting (0.44%), dizziness (0.15%), facial flushing (0.14%), and fatigue (0.12%).
These side effects may vary among individuals.
The above medications have been checked for interactions and can be taken together.
Experiencing shortness of breath after exercise may indicate angina or could be a normal phenomenon; it is advisable to discuss this with your physician or consider an exercise ECG.
Most importantly, maintain communication with your cardiologist and monitor your blood pressure closely.
Wishing you good health.
Reply Date: 2016/03/20
More Info
When managing heart conditions and hypertension, it is crucial to understand the potential risks and side effects associated with multiple medications. In your case, you are taking several medications, including Betaloc (10 mg), Amlodipine (5 mg), Carvedilol (160 mg), and Valsartan (10 mg), along with Tenormin (60 mg) and another medication for sleep, along with calcium carbonate.
Understanding Your Medications
1. Betaloc (Metoprolol): This is a beta-blocker that helps lower blood pressure and heart rate. Common side effects include fatigue, dizziness, and potential worsening of asthma or bronchospasm in susceptible individuals.
2. Amlodipine: A calcium channel blocker that helps relax blood vessels. Side effects can include swelling of the ankles, flushing, and palpitations.
3. Carvedilol: Another beta-blocker that also has alpha-blocking properties. It can cause dizziness, fatigue, and low blood pressure.
4. Valsartan: An angiotensin receptor blocker (ARB) used for hypertension. Side effects may include dizziness, elevated potassium levels, and renal impairment.
5. Tenormin (Atenolol): Similar to Betaloc, it is used for hypertension and can cause fatigue and dizziness.
6. Sleep Medication (e.g., Lorazepam): This can cause sedation, dizziness, and dependency if used long-term.
7. Calcium Carbonate: Generally safe but can cause constipation and may interfere with the absorption of certain medications if taken simultaneously.
Risks of Polypharmacy
Taking multiple medications can lead to drug interactions and increased side effects. For instance, combining beta-blockers (like Betaloc and Tenormin) can amplify the risk of bradycardia (slow heart rate) and hypotension (low blood pressure). Additionally, the combination of medications that affect blood pressure can lead to significant fluctuations, causing symptoms like dizziness or fainting.
Side Effects and Monitoring
Given your symptoms of chest pain, rib discomfort, and shortness of breath, it is essential to monitor these closely. While some side effects may be manageable, persistent or severe symptoms warrant immediate medical attention. The addition of Tenormin may help with heart rhythm issues, but it is crucial to discuss any new or worsening symptoms with your healthcare provider.
Specific Concerns with Tenormin
Tenormin (Atenolol) can have side effects such as fatigue, dizziness, and potential respiratory issues. It is essential to take it as prescribed, and if you experience significant side effects, you should consult your physician. The recommendation to take it twice daily (morning and evening) is likely to maintain stable blood levels and control your symptoms effectively.
Recommendations
1. Regular Monitoring: Keep regular appointments with your healthcare provider to monitor your heart function and medication effects. This includes blood pressure checks and possibly blood tests to monitor kidney function and electrolyte levels.
2. Symptom Diary: Maintain a diary of your symptoms, noting when they occur and their severity. This can help your doctor make informed decisions about your treatment.
3. Medication Review: Discuss with your healthcare provider the necessity of each medication and potential alternatives that may have fewer side effects or interactions.
4. Lifestyle Modifications: Incorporate heart-healthy lifestyle changes, such as a balanced diet, regular exercise (as tolerated), and stress management techniques.
5. Emergency Plan: Have a plan in place for what to do if you experience severe symptoms, such as chest pain or shortness of breath.
In conclusion, while managing multiple heart medications can be complex, understanding each medication's role, potential side effects, and the importance of communication with your healthcare provider can significantly improve your treatment outcomes. Always consult your healthcare provider before making any changes to your medication regimen.
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