Managing Side Effects of Progesterone: What You Need to Know - Obstetrics and Gynecology

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Side effects of progesterone?


Dear Doctor: Due to a short high temperature phase in my basal body temperature, my doctor prescribed progesterone for me.
Previously, I was using a small white pill, but I suddenly experienced severe dizziness.
This time, I was switched to Apidra (or a similar medication), and my doctor instructed me to start taking it on day 18 of my cycle for a continuous period of 14 days.
However, on the second day of taking it, I experienced severe abdominal distension (constant bloating throughout the day) and excessive gas, making it impossible for me to work.
Should I continue taking it? Thank you.

Ms. Li, 30~39 year old female. Ask Date: 2016/03/25

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, if you feel unwell, it is advisable to discontinue use.
Wishing you good health.

Reply Date: 2016/03/25

More Info


Managing side effects of progesterone can be a challenging experience, especially when you are prescribed this hormone for specific medical reasons such as short luteal phases or other reproductive health issues. Progesterone is a crucial hormone in the menstrual cycle and pregnancy, but it can also lead to various side effects that can affect your daily life.

In your case, it seems that you have experienced significant side effects after switching to a different form of progesterone, specifically the medication "亞培德胎隆" (likely a brand name for a micronized progesterone). The symptoms you describe, including severe abdominal bloating and excessive gas, are not uncommon with progesterone therapy. These gastrointestinal side effects can occur due to the hormone's effects on the smooth muscle of the gastrointestinal tract, leading to slowed motility and increased gas production.

Here are some key points to consider regarding the management of side effects from progesterone:
1. Communication with Your Doctor: It is essential to communicate openly with your healthcare provider about the side effects you are experiencing. They can provide guidance on whether to continue the medication or consider alternative treatments. Do not stop taking any prescribed medication without consulting your doctor first.

2. Dosage and Administration: Sometimes, adjusting the dosage or the timing of when you take the medication can help mitigate side effects. For example, taking progesterone at night may help reduce daytime symptoms, as it can cause drowsiness in some individuals.

3. Dietary Adjustments: If you are experiencing bloating and gas, consider making dietary changes. Avoiding carbonated beverages, high-fiber foods, and certain dairy products may help alleviate these symptoms. Keeping a food diary can also help identify any specific triggers.

4. Hydration and Exercise: Staying well-hydrated and incorporating light physical activity can help improve gastrointestinal motility and reduce bloating. Gentle exercises like walking or yoga can be beneficial.

5. Alternative Medications: If the side effects are intolerable, your doctor may suggest trying a different formulation of progesterone or an alternative treatment altogether. There are various forms of progesterone available, including oral tablets, vaginal suppositories, and injections, each with different side effect profiles.

6. Monitoring Symptoms: Keep a detailed record of your symptoms, including when they occur and their severity. This information can be invaluable for your healthcare provider in determining the best course of action.

7. Understanding Side Effects: It's important to recognize that while side effects can be bothersome, they are often temporary. Many individuals find that their bodies adjust to the medication over time, leading to a reduction in side effects.

In conclusion, while progesterone can be an effective treatment for various reproductive health issues, it is not without its challenges. If you are experiencing severe side effects, it is crucial to consult with your healthcare provider to discuss your symptoms and explore potential adjustments to your treatment plan. Your health and comfort should always be the priority, and there are often multiple options available to manage your condition effectively.

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