Morning Swelling: Possible Causes and Kidney Function Concerns - Internal Medicine

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Upon waking up in the morning, I noticed that my entire body was swollen?


My mother-in-law is fifty years old and has a family history of diabetes.
She is currently taking medication to manage her condition.
Over the past year, she has experienced swelling in her hands, feet, and face every morning upon waking.
I am unsure what this could indicate and whether it is related to kidney function.

Liu, 20~29 year old female. Ask Date: 2002/09/02

Dr. Xiao Yongxun reply Internal Medicine


Hello: In response to your question: (1) There are many causes of edema, generally classified as follows: 1.
Increased venous pressure: including congestive heart failure, valvular heart disease, pericardial disease, renal disorders, endocrine diseases, vascular disorders, etc.
2.
Hypoalbuminemia: including liver disorders, malnutrition, albumin loss, etc.
3.
Microvascular edema: allergies, vasculitis, idiopathic edema, etc.
4.
Lymphedema: congenital abnormalities, lymphatic metastasis, iatrogenic lymphedema, etc.
5.
Drug-induced edema: including non-steroidal anti-inflammatory drugs, antihypertensive medications, hormones, and psychiatric steroids, etc.
(2) Complications of diabetes include nephropathy, neuropathy, retinopathy, cardiovascular disease, cerebrovascular disease, among others, and other diseases may also occur concurrently with diabetes.
The cause of edema cannot be differentiated online.
(3) Therefore, it is advisable for your mother-in-law to visit an internal medicine outpatient clinic for a comprehensive evaluation before making any decisions.

Reply Date: 2002/09/02

More Info


Morning swelling, particularly in the hands, feet, and face, can be a concerning symptom, especially in someone with a family history of diabetes. In your mother-in-law's case, there are several potential causes for this swelling, and it is important to consider the relationship between her symptoms and kidney function.

Firstly, edema (swelling) can occur for various reasons, including fluid retention, inflammation, or underlying medical conditions. In the context of kidney function, the kidneys play a crucial role in regulating fluid balance in the body. If the kidneys are not functioning properly, they may struggle to excrete excess fluid, leading to swelling. This is particularly relevant for individuals with diabetes, as diabetic nephropathy (kidney disease resulting from diabetes) can develop over time, affecting kidney function.

In addition to kidney issues, other potential causes of morning swelling include:
1. Dietary Factors: High sodium intake can lead to fluid retention. If your mother-in-law's diet is high in salt, it may contribute to her swelling.

2. Medications: Some medications, including those for diabetes, can cause fluid retention as a side effect. It would be beneficial to review her medication list with her healthcare provider.

3. Hormonal Changes: Hormonal fluctuations, particularly in women, can lead to fluid retention. This is often seen during menstrual cycles or menopause.

4. Heart Function: Conditions affecting heart function can also lead to edema. If the heart is not pumping effectively, fluid can accumulate in the extremities and face.

5. Liver Function: Liver diseases can lead to fluid retention as well, particularly if there is a condition like cirrhosis.

Given her family history of diabetes, it is essential to monitor her kidney function regularly. A simple blood test measuring serum creatinine and a urinalysis can provide insight into her kidney health. If there are signs of proteinuria (protein in the urine) or elevated creatinine levels, it may indicate that her kidneys are not functioning optimally.

In summary, morning swelling in your mother-in-law could be related to her kidney function, particularly if she has underlying diabetes. However, it is essential to consider other potential causes as well. I recommend that she consults her healthcare provider for a thorough evaluation, including blood tests and possibly imaging studies, to determine the underlying cause of her swelling and to assess her kidney function. Early detection and management of any kidney issues are crucial, especially for individuals with diabetes, to prevent further complications.

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