Bruising and Bleeding: Could It Be Leukemia? - Internal Medicine

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Bruising and bleeding during brushing?


Hello, doctor.
I have two or three unexplained bruises on my body and I've been experiencing bleeding while brushing my teeth, so I went for blood tests.
My white blood cell count was normal, and I had two tests done about a month apart.
My coagulation function (PT and PTT) was also normal, and my liver function is normal as well.
However, I am still very worried that I might have leukemia.
Is it still possible for me to have leukemia under these circumstances? If I did have leukemia, would my white blood cells, red blood cells, and platelets definitely be abnormal? Do I need to undergo a bone marrow biopsy for further confirmation? Thank you, doctor.

Qiu Rongjing, 30~39 year old female. Ask Date: 2016/04/13

Dr. Xiao Yongxun reply Internal Medicine


Dear Mr.
Chiu Rong-Ching:
1.
Leukemia, also known as blood cancer, is characterized by the abnormal and uncontrolled proliferation of precursor cells of granulocytes, lymphocytes, monocytes, or leukocytes, leading to a reduction in normal white blood cells.
It includes acute lymphoblastic leukemia, acute myeloid leukemia, chronic lymphocytic leukemia, and chronic myeloid leukemia, among others.
The etiologies include exposure to radiation, drug effects, and viral infections.
The clinical symptoms primarily consist of anemia, increased susceptibility to infections, and a tendency to bleed.
Additionally, gastrointestinal symptoms, bone and joint pain, organ enlargement, lymphadenopathy, gum hypertrophy, central nervous system involvement, and skin infiltration may also occur.
2.
You have reported experiencing bruising and gum bleeding; however, your white blood cell count is normal, and coagulation function tests are also normal.
Based on this information, the likelihood of leukemia is low.
3.
Although the manifestations of leukemia primarily involve changes in the white blood cell series, it is indeed possible for abnormalities in red blood cells and platelets to occur as well.
However, the hematological abnormalities and presentations of various types of leukemia can differ significantly and should not be generalized.
4.
I believe you should have a thorough discussion with the physician who is examining you to consider whether a bone marrow aspiration is necessary.
5.
Furthermore, regarding the bruising and bleeding, leukemia is not the only possible cause.
Nutritional deficiencies, allergies, infections, inflammatory responses, medications, congenital disorders, metabolic abnormalities, uremia, and abnormalities in platelet count and function could also be contributing factors.
It is essential to work closely with your attending physician to investigate these possibilities further.

Reply Date: 2016/04/13

More Info


Bruising and bleeding can indeed be concerning symptoms, and your worries about leukemia are understandable. However, based on the information you've provided, it seems that you have undergone several important tests that can help rule out leukemia and other serious conditions.

Leukemia is a type of cancer that affects the blood and bone marrow, leading to the production of abnormal white blood cells. Common symptoms of leukemia include fatigue, frequent infections, easy bruising or bleeding, and unexplained weight loss. In your case, you mentioned having a few unexplained bruises and bleeding while brushing your teeth, which can be alarming. However, the fact that your white blood cell (WBC) count is normal, along with normal coagulation tests (PT and PTT), is a positive sign.

Typically, in cases of leukemia, one would expect to see abnormalities in the complete blood count (CBC), including elevated or decreased white blood cells, low red blood cells (anemia), and low platelet counts (thrombocytopenia). Since your WBC count is normal and you have not reported any significant abnormalities in your red blood cells or platelets, this makes leukemia less likely.

It's important to note that while bruising and bleeding can be associated with leukemia, they can also occur due to a variety of other reasons, such as minor trauma, certain medications (like blood thinners), or even conditions affecting platelet function. Additionally, some individuals may have a tendency to bruise easily without any underlying serious condition.

Regarding your question about whether leukemia would always show abnormalities in blood counts, the answer is generally yes. However, there are rare cases, especially in the early stages of the disease or in specific types of leukemia, where blood counts may appear normal. This is why further investigation may sometimes be warranted.

As for the bone marrow biopsy, it is a more invasive procedure that is typically reserved for cases where there is a strong suspicion of a hematological malignancy, or when blood tests indicate abnormalities that need further clarification. Given that your blood tests have returned normal results, it may not be necessary at this time. However, if your symptoms persist or worsen, or if new symptoms arise, discussing the possibility of a bone marrow biopsy with your healthcare provider would be a reasonable step.

In summary, while your symptoms are certainly worth monitoring, the normal results from your blood tests are reassuring. It is essential to maintain open communication with your healthcare provider, who can help assess your symptoms in the context of your overall health and guide you on any further necessary evaluations. If you continue to experience unexplained bruising or bleeding, or if you have any new symptoms, do not hesitate to seek further medical advice.

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