Drug Allergies: Antihistamines and Steroids in Urticaria Treatment - Dermatology

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Understanding drug allergies, particularly in the context of antihistamines and steroids used in the treatment of urticaria (hives), is crucial for effective management and patient safety.
Urticaria is characterized by the sudden appearance of itchy welts or hives on the skin, which can be triggered by various factors, including allergens, medications, infections, and stress. The first line of treatment typically involves antihistamines, which work by blocking the action of histamine, a substance in the body that causes allergic symptoms. In your case, the doctor prescribed an antihistamine (likely a second-generation antihistamine like Loratadine, known as "樂抗敏膜衣錠") to help alleviate the symptoms.
However, if the antihistamine alone is not effective, corticosteroids (like "康速龍錠") may be added to reduce inflammation and suppress the immune response. Corticosteroids are powerful anti-inflammatory medications that can help control severe allergic reactions and are often used in cases of acute urticaria when symptoms are extensive or persistent.

It is important to note that while antihistamines and corticosteroids are generally safe and effective for treating allergic reactions, there are instances where patients may experience adverse reactions or allergies to these medications. This can occur for several reasons:
1. Individual Sensitivity: Some individuals may have a unique sensitivity to certain components of the medication, leading to an allergic reaction despite the drug's intended purpose of alleviating allergy symptoms.

2. Cross-Reactivity: In some cases, patients who are allergic to one substance may also react to chemically similar substances, including certain medications.

3. Delayed Reactions: Allergic reactions can sometimes be delayed, meaning that symptoms may not appear until after several doses of the medication have been taken.

4. Underlying Conditions: Patients with chronic urticaria or other underlying conditions may have a more complex response to medications, leading to unexpected reactions.

Regarding your specific situation, if you have noticed an increase in hives after taking the corticosteroids and antihistamines, it is essential to communicate this to your healthcare provider. They may recommend discontinuing the corticosteroid or adjusting your treatment plan.
As for continuing the use of the antihistamine (柏那錠), it is generally safe to continue taking antihistamines unless you experience a specific allergic reaction to that medication. However, if you are experiencing worsening symptoms, it is crucial to consult your doctor before making any changes to your medication regimen.

In summary, while antihistamines and corticosteroids are effective in treating urticaria, individual responses can vary, and allergic reactions to these medications can occur. It is vital to work closely with your healthcare provider to monitor your symptoms and adjust your treatment as necessary. If your symptoms persist or worsen, further evaluation may be needed to identify the underlying cause and appropriate management strategies.