Progesterone Dosage: Is Too Much Harmful for Pregnancy? - Obstetrics and Gynecology

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Dosage of progesterone?


Hello Doctor, I would like to ask if there is a risk of overdose with progesterone (Utrogestan and Duphaston).
During my previous pregnancy, my doctor prescribed me to take 2 pills a day.
Now, I am over 6 weeks pregnant with a heartbeat, and another doctor has advised me to take 4 pills a day.
Is this dosage considered high? I am concerned about whether excessive progesterone could have adverse effects on the baby.
Thank you, Doctor.

kiki, 30~39 year old female. Ask Date: 2016/04/21

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, are you a patient with infertility or recurrent miscarriages? If not, if the fetus has a heartbeat, medication may not be necessary.
If medication is taken, taking four pills a day is still acceptable.
Wishing you good health.

Reply Date: 2016/04/21

More Info


When it comes to the use of progesterone during pregnancy, particularly in the form of medications like Utrogestan, it is essential to understand both the benefits and potential risks associated with its dosage. Progesterone is a hormone that plays a crucial role in maintaining pregnancy, especially in the early stages. It helps to prepare the uterine lining for implantation of the embryo and supports the pregnancy by preventing uterine contractions that could lead to miscarriage.

In your case, you mentioned that one doctor prescribed you to take two capsules of progesterone daily during your previous pregnancy, while another doctor has now recommended a dosage of four capsules daily in your current pregnancy, which is at six weeks with a confirmed heartbeat. It is understandable to be concerned about the implications of taking a higher dosage of progesterone.

Firstly, it is important to note that progesterone is generally considered safe during pregnancy, especially when prescribed by a healthcare provider. The dosage of progesterone can vary based on individual circumstances, including the presence of any complications such as a history of miscarriage or other medical conditions that may necessitate higher levels of progesterone. The standard dosages can range widely, and in some cases, higher doses are used to ensure adequate hormone levels to support the pregnancy.

Regarding your concern about taking four capsules daily, this dosage is not uncommon in certain clinical situations, particularly for women who have experienced issues with progesterone levels in the past. However, the safety of this dosage should always be evaluated in the context of your specific health situation and under the guidance of your healthcare provider.
Excessive progesterone levels can lead to side effects, but these are typically mild and may include symptoms such as fatigue, dizziness, or mood changes. In rare cases, very high levels of progesterone could potentially lead to complications, but these instances are not common and usually occur in the context of other underlying health issues.

It is crucial to maintain open communication with your healthcare provider about your concerns. If you feel uncertain about the prescribed dosage, do not hesitate to seek a second opinion or discuss your worries with your doctor. They can provide you with personalized advice based on your medical history and the specifics of your current pregnancy.

In summary, while progesterone is essential for a healthy pregnancy, the appropriate dosage can vary significantly from one individual to another. The increase from two to four capsules may be warranted based on your medical history and current pregnancy status. Always prioritize discussing any concerns with your healthcare provider to ensure the best outcome for both you and your baby. Regular monitoring and follow-up appointments are also essential to assess the health of your pregnancy and make any necessary adjustments to your treatment plan.

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