Differentiating Between Lip Blisters and Salivary Gland Cysts - Otolaryngology

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Salivary gland cyst


I had a salivary gland cyst surgery in mid-March this year, and now, just over a month later, I have a small blister on my lip (I've been careful not to bite my lip...).
Although it's not as large as the last one, I would like to know how to differentiate between a blister and a salivary gland cyst.

SF, 20~29 year old female. Ask Date: 2016/04/23

Dr. Zheng Jueyi reply Otolaryngology


Hello: Although they appear very similar, most blisters will resolve, while salivary gland cysts tend to recur frequently.
Wishing you peace and health.
Sincerely, Dr.
Cheng Jue-Yi, Director of the Department of Otolaryngology, Taoyuan Hospital, Ministry of Health and Welfare.

Reply Date: 2016/04/23

More Info


When it comes to differentiating between lip blisters and salivary gland cysts, it is essential to understand the characteristics, causes, and symptoms of each condition. Both can present as swelling or bumps in the oral cavity, but they have distinct features that can help in their identification.

Lip Blisters:
Lip blisters are typically small, fluid-filled sacs that can occur on the lips or surrounding areas. They are often caused by various factors, including:
1. Herpes Simplex Virus (HSV): The most common cause of lip blisters is a herpes outbreak, which can lead to cold sores. These blisters may be painful, itchy, and can rupture, leading to crusting and healing over a week or two.

2. Trauma or Irritation: Blisters can also form due to physical irritation, such as biting the lip, sunburn, or allergic reactions to products like lip balm or cosmetics.

3. Allergic Reactions: Contact dermatitis from allergens can cause blistering on the lips.

4. Infections: Other viral or bacterial infections can also lead to blister formation.

Salivary Gland Cysts:
Salivary gland cysts, on the other hand, are typically larger, more firm, and can be painless. They are often caused by:
1. Obstruction: A blockage in the salivary duct can lead to the accumulation of saliva, forming a cyst. This can occur due to dehydration, medications, or other factors that reduce saliva flow.

2. Infection: Infections in the salivary glands can lead to the formation of cysts or abscesses.

3. Trauma: Previous trauma to the area, such as surgery (as in your case), can also result in cyst formation.

4. Mucoceles: These are specific types of cysts that occur when a salivary gland duct is damaged, leading to the leakage of saliva into the surrounding tissue.

Differentiating Factors:
To differentiate between the two, consider the following:
- Location and Size: Lip blisters are usually smaller and localized to the lip area, while salivary gland cysts can be larger and may be located inside the mouth or under the tongue.

- Pain and Symptoms: Lip blisters, especially those caused by HSV, are often painful and may be accompanied by itching or burning sensations. Salivary gland cysts are generally painless unless infected.

- Duration: Lip blisters typically resolve within a week or two, while salivary gland cysts may persist longer and require medical evaluation if they do not resolve.

- Associated Symptoms: If you experience fever, swelling, or increased pain, it may indicate an infection, which could complicate the cyst or suggest another issue.

Given that you recently underwent surgery for a salivary gland cyst, it is crucial to monitor the new swelling closely. If the blister persists, changes in appearance, or is accompanied by pain or other symptoms, it is advisable to consult your healthcare provider for an accurate diagnosis. They may perform a physical examination and, if necessary, imaging studies to determine the nature of the swelling.

In summary, while both lip blisters and salivary gland cysts can appear similar, their characteristics, causes, and associated symptoms can help in distinguishing between the two. If there is any doubt or concern, seeking medical advice is always the best course of action to ensure proper diagnosis and treatment.

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