Can Helicobacter Pylori Cause Stomach Discomfort Without Inflammation or Ulcers? - Gastroenterology and Hepatology

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The gastroscopy showed no inflammation or ulcers in the stomach, but there is mild gastroesophageal reflux. However, Helicobacter pylori was detected?


Hello, doctor.
For the past two weeks, I have been experiencing discomfort in my stomach, including dull pain, bloating, and indigestion.
However, I underwent an endoscopy yesterday, and there was no inflammation or ulcers in my stomach, just mild gastroesophageal reflux.
The test did detect Helicobacter pylori.
Can H.
pylori still cause the aforementioned stomach discomfort symptoms even in the absence of inflammation or ulcers?

Hank, 20~29 year old female. Ask Date: 2016/05/03

Dr. Chen Qifeng reply Gastroenterology and Hepatology


Helicobacter pylori can naturally exist in a normal, healthy stomach, so it is not necessarily associated with gastritis or ulcers.
Based on the symptoms, it may simply be indigestion.
Of course, if eradication therapy is administered, it may also help improve the symptoms.

Reply Date: 2016/05/03

More Info


Helicobacter pylori (H. pylori) is a type of bacteria that can inhabit the stomach lining and is known for its association with various gastrointestinal disorders, including gastritis, peptic ulcers, and even gastric cancer. However, it is important to note that H. pylori can also exist in the stomach without causing any noticeable symptoms or inflammation.
In your case, you mentioned experiencing stomach discomfort, bloating, and indigestion, despite the absence of inflammation or ulcers as confirmed by your endoscopy. This raises an important question: can H. pylori still be responsible for these symptoms even when no inflammation or ulcers are present?
The answer is yes; H. pylori can indeed cause gastrointestinal discomfort without leading to overt inflammation or ulceration. The presence of H. pylori can disrupt the normal balance of the stomach environment, leading to symptoms such as bloating, discomfort, and dyspepsia (indigestion). This is often due to the bacteria's ability to alter gastric acid secretion and affect the mucosal barrier of the stomach, which can lead to symptoms even in the absence of visible damage.

Moreover, H. pylori is known to be a chronic infection in many individuals, and its presence can lead to functional dyspepsia, a condition characterized by persistent or recurrent pain or discomfort in the upper abdomen without any identifiable organic cause. This means that even if your endoscopy shows no signs of inflammation or ulcers, the presence of H. pylori could still be contributing to your symptoms.

It is also worth noting that the symptoms you are experiencing could be multifactorial. Factors such as diet, stress, and lifestyle choices can significantly impact gastrointestinal health. For instance, if you have been under stress or have made recent changes to your diet, these could exacerbate your symptoms. Additionally, conditions like gastroesophageal reflux disease (GERD) can also lead to similar symptoms, and you mentioned experiencing mild acid reflux.

Regarding the management of H. pylori, if your symptoms persist, it may be beneficial to discuss with your healthcare provider the possibility of undergoing eradication therapy. This typically involves a combination of antibiotics and proton pump inhibitors (PPIs) to eliminate the bacteria and reduce stomach acid, which can help alleviate symptoms.

In conclusion, while H. pylori is often associated with inflammation and ulcers, it can also cause discomfort and dyspeptic symptoms in the absence of these conditions. If your symptoms continue, it is advisable to have a thorough discussion with your healthcare provider about the potential role of H. pylori in your case and consider appropriate treatment options. Additionally, addressing lifestyle factors and dietary habits may also play a crucial role in managing your symptoms effectively.

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