Interactions Between Doxycycline and Common Supplements: What You Need to Know - Pharmacology

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Medications for treating vitiligo and whitening injections?


Hello, Director Huang.
Recently, I have been taking Doxycycline to treat Chlamydia infection and FROTIN ENTERIC SUGAR COATED oral antifungal suppositories for vaginal yeast infection.
I usually receive injections for maintenance.
I would like to know if the following substances will conflict with my treatment medications:
1.
Ascorbic Acid (high-dose Vitamin C)
2.
Tranexamic Acid
3.
Thioctic Acid (Alpha-Lipoic Acid)
4.
B-complex vitamins
5.
Glycyrrhizinate (Licorice Root Extract)
6.
Glutathione
7.
Ginkgo Biloba
8.
Glutamine
Which of the above substances are not suitable for use during my treatment? If permissible, how long should I wait between administering these substances and my medications?

J, 20~29 year old female. Ask Date: 2016/05/05

Dr. Huang Shenggang reply Pharmacology


Hello, generally speaking, interactions between oral medications and injectable treatments are rare.
If you have concerns, please ask your physician for the medication guide when receiving the injection, where you can find relevant precautions.
Alternatively, you can proactively inform your physician about any medications you are currently taking.
Thank you for your question.

Reply Date: 2016/05/05

More Info


When considering the interactions between Doxycycline and various supplements, it is essential to understand how these substances can affect each other, particularly in the context of treating infections such as Chlamydia and fungal infections. Doxycycline is a broad-spectrum antibiotic that belongs to the tetracycline class and is commonly used to treat a variety of bacterial infections. However, it can interact with certain supplements and medications, which may affect its efficacy or lead to adverse effects.

1. Ascorbic Acid (Vitamin C): Generally, Vitamin C does not have significant interactions with Doxycycline. However, high doses of Vitamin C may alter the absorption of certain antibiotics. It is advisable to take them at different times to avoid any potential interference. A gap of at least 2 hours is recommended.

2. Tranexamic Acid: This medication is primarily used to reduce bleeding and does not have known interactions with Doxycycline. However, as with any medication, it is best to consult with a healthcare provider regarding concurrent use.

3. Thioctic Acid (Alpha-Lipoic Acid): There is limited information on the interaction between Thioctic Acid and Doxycycline. While it is generally considered safe, it is prudent to space them out by at least 2 hours.

4. Vitamin B Complex: B vitamins are essential for various metabolic processes and do not typically interact negatively with Doxycycline. However, it is still wise to take them at different times to ensure optimal absorption of both.

5. Glycyrrhizinate (Licorice Acid): Glycyrrhizinate can affect cortisol metabolism and may lead to increased blood pressure or potassium depletion. While there are no direct interactions with Doxycycline, caution is advised, especially if you have underlying health conditions.

6. Glutathione: This antioxidant does not have known interactions with Doxycycline and can be taken concurrently. However, spacing them out by a couple of hours is still a good practice.

7. Ginkgo Biloba: Ginkgo can affect blood clotting and may interact with other medications. While there is no direct interaction with Doxycycline, it is advisable to consult your healthcare provider, especially if you are on anticoagulants or have bleeding disorders.

8. Glutamine: This amino acid is generally safe to take with Doxycycline and does not have known interactions. However, as a precaution, taking them at different times is recommended.

In summary, while many of the supplements listed do not have significant interactions with Doxycycline, it is always best to take them at different times to avoid any potential absorption issues. A general rule of thumb is to space out medications and supplements by at least 2 hours. Additionally, always consult with your healthcare provider before starting any new supplements, especially when undergoing treatment for infections, to ensure that there are no contraindications or potential adverse effects based on your overall health status and other medications you may be taking.
Maintaining open communication with your healthcare provider about all medications and supplements you are taking is crucial for safe and effective treatment.

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