Lung Cavities: Concerns About Treatment and Diagnosis - Pulmonology

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Pulmonary cavity


Hello Doctor: Previously, I inquired about my mother's issue with coughing up blood.
Today, we received the report results, which indicate that there is a cavity in her lungs, and the sputum culture shows the presence of Pseudomonas aeruginosa.
I forgot to ask whether it was a positive or negative reaction.
The doctor reported and treated her as a suspected case of tuberculosis, but no further tests were conducted.
Since there is a bacterial infection, shouldn't it be treated with antibiotics? Why prescribe tuberculosis medication? The lung cavity could potentially indicate pneumothorax or hemothorax, but my mother has diabetes, liver cirrhosis, and splenomegaly, and she is already on multiple medications.
I'm concerned that adding tuberculosis medication could lead to significant side effects.
Should we seek evaluation from another hospital?

Lin, 20~29 year old female. Ask Date: 2016/05/17

Dr. Yang Wenda reply Pulmonology


Hello: In cases of lung inflammation or the presence of cavities (which is different from pneumothorax or hemothorax), it is possible for two or more pathogenic bacteria to coexist.
If there is no significant improvement in the lesions after antibiotic treatment for Pseudomonas aeruginosa, one may suspect the presence of tuberculosis (even if acid-fast bacilli are not necessarily seen in the sputum smear).
For patients with liver cirrhosis, liver function should be monitored during the course of antitubercular therapy.
Best wishes!

Reply Date: 2016/05/17

More Info


Understanding lung cavities and their implications for treatment and diagnosis is crucial, especially in the context of your mother's health concerns. The presence of a lung cavity, particularly in conjunction with a positive culture for Pseudomonas aeruginosa (the green rod bacteria you mentioned), raises several important considerations.

Firstly, the identification of a lung cavity can be indicative of various underlying conditions, including infections, malignancies, or chronic inflammatory processes. In your mother's case, the suspicion of tuberculosis (TB) is significant. TB can lead to cavitary lesions in the lungs, and the treatment protocol for suspected TB often involves a combination of antibiotics specifically designed to target Mycobacterium tuberculosis. This is likely why the physician initiated treatment with anti-TB medications, even in the presence of a bacterial infection.

It's important to note that while Pseudomonas aeruginosa is a common pathogen in various lung infections, especially in patients with underlying conditions like diabetes or chronic lung disease, the treatment for TB is distinct due to the nature of the bacteria involved. The decision to treat for TB may stem from the clinical presentation, the imaging findings, and the laboratory results, which suggest a more serious underlying infection that could have significant implications if left untreated.

Given your mother's complex medical history, including diabetes, liver cirrhosis, and splenomegaly, the introduction of new medications, particularly those used for TB, should be approached with caution. These medications can have side effects, and the potential for drug interactions with her current medications is a valid concern. For instance, some anti-TB drugs can affect liver function, which is particularly important in patients with pre-existing liver conditions.

In light of these factors, seeking a second opinion or further evaluation from another healthcare provider is a prudent step. A specialist, such as a pulmonologist or an infectious disease expert, can provide a more comprehensive assessment of your mother's condition. They may recommend additional diagnostic tests, such as a bronchoscopy, further imaging studies, or even a biopsy of the lung tissue to clarify the nature of the cavity and the best course of treatment.

Moreover, it is essential to monitor her overall health closely during this period. Regular follow-ups and communication with her healthcare team will help manage her existing conditions while addressing the new concerns regarding her lung health. If she experiences any new symptoms, such as increased shortness of breath, chest pain, or significant changes in her cough, these should be reported immediately to her healthcare provider.

In summary, while the presence of a lung cavity and the positive culture for Pseudomonas aeruginosa are concerning, the initiation of TB treatment is likely a precautionary measure based on the clinical context. Given your mother's complex health status, obtaining a second opinion and ensuring close monitoring of her treatment plan is advisable to mitigate potential risks and ensure the best possible outcomes.

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