Hepatitis B Carriers: Symptoms and Concerns - Internal Medicine

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Hepatitis B carrier


I am a carrier of hepatitis B, but I have never experienced symptoms of hepatitis.
I have always felt that my appearance is not very good and I tend to have a lot of heat in my body.
In recent years, I have felt increasing pressure in the area near my liver, and I feel discomfort when sleeping on my left side.
Three months ago, I started taking Lamivudine and an immunomodulatory agent.
Two weeks ago, my ALT was 68 and AST (GOT) was 98.
However, in the past week, the pressure in the area near my liver has been increasing, and it feels like bloating from within, especially after eating a full meal.
Other than that, I have not noticed any other abnormalities.
Could this be the beginning of cirrhosis? However, an ultrasound three months ago showed no issues.
Thank you for your response, doctor!

Jiànkāng, 20~29 year old female. Ask Date: 2000/11/16

Dr. Chen Shidian reply Internal Medicine


Hello: 1.
Liver distension and pain may be related to hepatitis, but it could also simply be due to gastrointestinal dyspepsia, and is mostly unrelated to liver cirrhosis.
2.
Immunomodulatory agents are not conventional treatment medications, so please use them with caution.
3.
GOT 98, GPT 68, but the original values are unknown.
Is HBeAg (Hepatitis B e antigen) positive? Wishing you safety.

Reply Date: 2000/11/16

More Info


As a Hepatitis B carrier, your concerns regarding symptoms and potential complications are valid and warrant careful consideration. Hepatitis B is a viral infection that can lead to chronic liver disease, and while many carriers may remain asymptomatic for years, it is crucial to monitor liver health regularly.


Understanding Hepatitis B and Its Symptoms
Hepatitis B is primarily transmitted through blood and bodily fluids. Once infected, the virus can remain in the liver, leading to either acute or chronic hepatitis. Chronic carriers may not exhibit symptoms for long periods, but they can still experience liver inflammation, which can lead to more severe complications like cirrhosis or liver cancer over time.

Your description of feeling pressure in the liver area, especially after eating, could be indicative of several issues. While it is not uncommon for individuals with chronic hepatitis to experience discomfort or a sensation of fullness in the upper abdomen, it is essential to differentiate between benign symptoms and those that may signal more serious liver damage.


Monitoring Liver Function
Your recent lab results showing ALT (alanine aminotransferase) at 68 and AST (aspartate aminotransferase) at 98 indicate mild liver inflammation. Normal ranges for ALT and AST are typically below 40 U/L, so your values suggest that there is some level of liver stress. The fact that you have been on Lamivudine, an antiviral medication, is a positive step in managing your hepatitis B. However, the increasing pressure in your abdomen, particularly after meals, should not be overlooked.


Potential Complications
The sensation of pressure and discomfort could be due to several factors, including:
1. Liver Inflammation: Ongoing inflammation can cause discomfort. Even if your ultrasound was normal three months ago, liver inflammation can fluctuate.


2. Fatty Liver Disease: This condition can coexist with hepatitis B and may contribute to abdominal discomfort. It is often related to diet and lifestyle factors.

3. Early Signs of Fibrosis or Cirrhosis: While your ultrasound did not show abnormalities, chronic hepatitis can lead to fibrosis, which may not always be visible on imaging until it is more advanced.

4. Gastrointestinal Issues: Sometimes, discomfort in the liver area may stem from gastrointestinal problems rather than liver pathology.


Recommendations
1. Follow-Up with Your Healthcare Provider: Given your symptoms and lab results, it is crucial to have a thorough evaluation by a hepatologist or a gastroenterologist. They may recommend additional imaging studies, such as a FibroScan, to assess liver stiffness, which can indicate fibrosis or cirrhosis.

2. Monitor Symptoms: Keep track of any changes in your symptoms, especially if they worsen or if you develop new symptoms like jaundice, severe fatigue, or significant changes in appetite.

3. Lifestyle Modifications: Maintaining a healthy diet, avoiding alcohol, and managing weight can help reduce liver stress. Regular exercise and a balanced diet can also improve overall liver health.

4. Regular Monitoring: Regular blood tests to monitor liver function and viral load are essential in managing chronic hepatitis B. This will help your healthcare provider make informed decisions about your treatment plan.

5. Consider a Second Opinion: If you feel uncertain about your current treatment or diagnosis, seeking a second opinion can provide additional insights and options.


Conclusion
While your symptoms may not necessarily indicate the onset of cirrhosis, they do warrant further investigation. It is essential to remain vigilant about your liver health and maintain open communication with your healthcare provider. Regular monitoring and proactive management are key to living well with hepatitis B and minimizing the risk of complications.

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