Chocolate Cysts: Key Questions and Concerns for Women - Obstetrics and Gynecology

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Chocolate cyst


Hello, Doctor.
I would like to ask a few questions about chocolate cysts.
Here is my situation: In mid-November last year, during my company's annual health check-up, a cyst on my ovary was suspected.
A little over a week after the check-up, I got my period.
In May of this year, I visited a gynecologist for an examination.
During my first visit, the doctor ordered a blood test for CA-125.
During my second follow-up, we reviewed the CA-125 level and ultrasound results.
At that time, my CA-125 level was 41, and the ultrasound also showed a cyst.
I would like to ask: 1.) During my first visit to the clinic for the blood test, I had acute stomach pain the day before.
Could this affect the CA-125 level? 2.) Since my second follow-up coincided with my upcoming period (as seen on the ultrasound), I would like to know if the timing of my examinations in mid-November last year and today, both occurring 1-2 weeks before my period, could affect the ultrasound results? 3.) Is it possible that the ultrasound results from both visits were just capturing normal follicles? 4.) If I want to undergo further testing, should I wait until after my period to have blood drawn and an ultrasound?

Miss E, 30~39 year old female. Ask Date: 2016/05/30

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, the best time for an ultrasound is after the menstrual period ends, and it is less related to other factors.
It is recommended to continue follow-up examinations with your original obstetrician-gynecologist.
Wishing you good health.

Reply Date: 2016/05/30

More Info


Understanding chocolate cysts, also known as endometriomas, is crucial for women who may be experiencing related symptoms or have been diagnosed with them. These cysts are a manifestation of endometriosis, where endometrial tissue grows outside the uterus, often on the ovaries. They can cause pain, irregular menstruation, and fertility issues. Your questions touch on important aspects of diagnosis and monitoring, particularly regarding the CA-125 blood test and ultrasound imaging.

1. Impact of Acute Gastric Pain on CA-125 Levels: The CA-125 test measures the level of a protein that can be elevated in various conditions, including endometriosis, pelvic inflammatory disease, and certain cancers. Acute gastric pain or any acute illness can potentially influence CA-125 levels, but it is generally more affected by conditions related to the reproductive system. Stress and inflammation from any source can lead to elevated CA-125 levels, but it is essential to interpret these results in the context of your overall health and any underlying conditions.

2. Timing of Menstrual Cycle and Ultrasound Results: The timing of your ultrasound in relation to your menstrual cycle can indeed affect the results. Ultrasound imaging is most effective when performed at specific times in the cycle. For instance, performing an ultrasound just before menstruation may show different ovarian structures, such as follicles or cysts, compared to imaging done after menstruation. Follicles, which are normal fluid-filled sacs in the ovaries, can be mistaken for cysts if the timing is not optimal. Therefore, it is advisable to discuss with your healthcare provider the best timing for imaging based on your menstrual cycle.

3. Differentiating Between Cysts and Follicles: It is possible that the ultrasound findings could represent normal ovarian follicles rather than chocolate cysts. Follicular cysts are common and usually resolve on their own. However, chocolate cysts have a distinct appearance on ultrasound, often described as having a "ground-glass" echogenicity due to the thick, old blood within them. Your healthcare provider can help differentiate between these types of cysts based on their characteristics and your clinical history.

4. Timing for Further Testing: If you are considering further testing, it is generally recommended to schedule blood tests and ultrasounds after your menstrual period has ended. This timing allows for clearer imaging of the ovaries and can help avoid confusion with normal menstrual cycle changes. Additionally, it may provide a more accurate assessment of any cysts or abnormalities present.

In summary, understanding the nuances of chocolate cysts and the factors influencing diagnostic tests is essential for effective management. It is important to maintain open communication with your healthcare provider, who can guide you on the best practices for monitoring and managing your condition. If you have concerns about your CA-125 levels or ultrasound findings, discussing these with your doctor can help clarify the next steps and ensure appropriate care.

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