Core Needle Biopsy for Fibroadenomas and Sclerosing Adenosis - Surgery

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Core needle biopsy


Hello Dr.
Lee, I previously had two fibroadenomas excised, and the biopsy results indicated "sclerosing adenosis" and "hyperplasia." My most recent breast ultrasound showed approximately 11 lesions on both sides, and I am concerned that some of these may also exhibit "sclerosing adenosis." My past experiences with follow-ups suggest that "sclerosing adenosis" and "epithelial hyperplasia" on ultrasound appear similar to typical fibroadenomas or fibrocystic changes.
Therefore, I would like to ask:
1.
Can breast ultrasound truly differentiate between "sclerosing adenosis," simple fibroadenomas, or cysts? If so, how?
2.
Given that I currently have over ten lesions on both sides, how should I determine which ones require a core needle biopsy? If the biopsy results show "sclerosing adenosis" or "hyperplasia," would it be better to remove them?
3.
Is there a limit to the number of lesions that can be biopsied during a single clinic visit?
4.
Do complex cysts require a core needle biopsy?
Thank you for your answers.

Sincere, 40~49 year old female. Ask Date: 2016/07/01

Dr. Li Zhonghuai reply Surgery


Hello! The more concerning condition is sclerosing adenosis.
If atypical cells are observed in a core needle biopsy, it is recommended to remove the entire lesion to prevent the possibility of hidden carcinoma in situ.
Ultrasound can help differentiate between "sclerosing adenosis," simple fibroadenoma, or cysts, but if there is an increase in size, even a simple fibroadenoma should also undergo core needle biopsy.
There is no specific limit on the number of biopsies; if a complex cyst enlarges or is suspected to be malignant, a core needle biopsy is also recommended.
Essentially, no lesion should be overlooked, so close monitoring is necessary.
Take care! Changhua Hospital is concerned about you!

Reply Date: 2016/07/01

More Info


Understanding the nuances of breast pathology, particularly concerning fibroadenomas and sclerosing adenosis, is crucial for managing your health and alleviating concerns regarding breast lesions. Let’s address your questions systematically.

1. Differentiating Sclerosing Adenosis from Fibroadenomas on Ultrasound:
Ultrasound is a valuable tool in breast imaging, but it has limitations in distinguishing between different types of breast lesions. Fibroadenomas typically appear as well-defined, solid masses with smooth contours, while sclerosing adenosis may present as areas of increased echogenicity with a more heterogeneous appearance. However, both conditions can sometimes look similar on ultrasound, making it challenging to differentiate them solely based on imaging. A biopsy is often necessary to provide a definitive diagnosis, as histological examination can reveal the cellular characteristics that distinguish sclerosing adenosis from fibroadenomas.

2. Indications for Core Needle Biopsy:
The decision to perform a core needle biopsy (CNB) is based on several factors, including the size, shape, and characteristics of the lesions observed on imaging. If you have multiple lesions, the radiologist or your healthcare provider will typically prioritize biopsying those that exhibit atypical features, such as irregular borders, heterogeneous echogenicity, or significant changes compared to previous imaging studies. If a lesion is suspected to be sclerosing adenosis or shows hyperplasia, a biopsy may be warranted to rule out any potential malignancy. If the biopsy results indicate sclerosing adenosis or hyperplasia, the management will depend on the clinical context, including your age, family history, and any associated symptoms. In some cases, surgical excision may be recommended, especially if there are concerns about atypical hyperplasia or if the lesions are symptomatic.

3. Limitations on the Number of Lesions for Biopsy:
There is generally no strict limit on the number of lesions that can be biopsied during a single appointment; however, practical considerations such as patient comfort, the size of the lesions, and the expertise of the performing radiologist may influence this decision. If multiple lesions are present, the healthcare provider will typically focus on those that are most concerning based on imaging characteristics.

4. Need for Biopsy in Complex Cysts:
Complex cysts, which may contain both cystic and solid components, often require further evaluation. If a complex cyst has suspicious features, such as thickened walls or solid components, a core needle biopsy may be indicated to assess for potential malignancy. Conversely, if the complex cyst appears benign and stable over time, it may be monitored with follow-up imaging rather than subjected to biopsy.

In conclusion, while ultrasound is a useful tool for evaluating breast lesions, it often cannot definitively distinguish between conditions like fibroadenomas and sclerosing adenosis. Core needle biopsy remains the gold standard for obtaining a tissue diagnosis, particularly when there are concerns about atypical features. It’s essential to maintain open communication with your healthcare provider regarding your concerns and the best course of action for monitoring and managing your breast health. Regular follow-ups and imaging can help ensure any changes are promptly addressed.

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