Blood Test Results: Analyzing MCV, MCH, and Anemia Risks - Cardiology

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Complete Blood Count (CBC) Test


Hello, Doctor He.
I would like to ask about my blood test results.
In each of my approximately four complete blood count tests, my MCV (around 66), MCH (around 20), and MCHC (around 30) were all low, while my RBC count was high (around 7), but my hemoglobin level was normal (around 14.5).
Do these results from the four complete blood count tests not provide sufficient evidence to confirm that I have a carrier status for either thalassemia or iron deficiency anemia? Is a complete blood count only able to indicate the presence of anemia but not sufficient to test for the carrier status of thalassemia or iron deficiency anemia genes? Based on the results from my four complete blood count tests, do I need to declare that I am a carrier of thalassemia or iron deficiency anemia? Wishing you good health and success at work!

Xiao Li, 30~39 year old female. Ask Date: 2016/07/07

Dr. He Dongjin reply Cardiology


Hello, it seems you have latent thalassemia, but currently, there is no anemia and your hemoglobin level is normal at 14.5.
If you need a definitive diagnosis, please visit the Hematology outpatient clinic at Changhua Hospital for further evaluation.

Reply Date: 2016/07/07

More Info


Understanding blood test results can be quite complex, especially when it comes to interpreting specific indices such as MCV (Mean Corpuscular Volume), MCH (Mean Corpuscular Hemoglobin), and MCHC (Mean Corpuscular Hemoglobin Concentration). These parameters are crucial in assessing the size and hemoglobin content of red blood cells, which can provide insights into various types of anemia and other hematological conditions.

In your case, you mentioned that your MCV is around 66, MCH is about 20, and MCHC is approximately 30, all of which are considered low. A low MCV indicates that your red blood cells are smaller than normal, a condition known as microcytosis. Similarly, a low MCH suggests that the average amount of hemoglobin per red blood cell is reduced, which can also be indicative of certain types of anemia, particularly iron deficiency anemia or thalassemia (including the possibility of being a carrier of thalassemia genes).

Your RBC count being high (around 7) alongside normal hemoglobin levels (approximately 14.5) presents an interesting scenario. Typically, a high RBC count can sometimes compensate for low hemoglobin levels, but in your case, it may suggest that your body is producing more red blood cells in response to some underlying condition, possibly related to your low MCV and MCH values.

Regarding your question about whether these results can confirm or rule out the presence of thalassemia or iron deficiency anemia genes, it is important to note that while blood tests can indicate the presence of anemia, they do not definitively diagnose genetic conditions. Thalassemia, for example, can be inherited in a carrier state without showing significant symptoms or anemia. The presence of low MCV and MCH values can suggest the possibility of thalassemia or iron deficiency, but genetic testing is required to confirm whether you are a carrier of these conditions.

If you have consistently low MCV and MCH values across multiple tests, it may be prudent to discuss further testing with your healthcare provider. This could include iron studies (serum ferritin, serum iron, total iron-binding capacity) to assess for iron deficiency, as well as hemoglobin electrophoresis to evaluate for thalassemia or other hemoglobinopathies.
In summary, while your blood test results indicate some abnormalities that could suggest the presence of microcytic anemia, they do not definitively prove that you carry genes for thalassemia or iron deficiency anemia. It is advisable to have a thorough discussion with your healthcare provider about your results and consider further testing if there is a concern about your genetic status or if you experience any symptoms related to anemia. Regular monitoring and a comprehensive approach to your health will help ensure that any potential issues are addressed promptly.

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