Amphetamine Abuse: Managing Anger and Mental Health Concerns - Psychiatry

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Substance abuse


Hello, doctor.
Recently, my family discovered that my husband has been using methamphetamine for about 2 to 3 years.
He has lost control of his temper and becomes enraged under pressure.
We are concerned that he may have sustained brain damage, but he claims he does not experience hallucinations or auditory disturbances.
Does this mean his mental state is still considered normal? Although he has been persuaded to seek treatment at a hospital, why is it that after stopping methamphetamine use for two weeks (unless he is lying) and taking the medication prescribed by the doctor for one week (which resembles a sleeping pill and makes him very drowsy), he still frequently loses control of his temper and has a very low tolerance for frustration? How long should he continue to follow the doctor's medication regimen before he sees significant improvement or control over these withdrawal symptoms? Additionally, should we request the doctor to arrange for brain imaging during his follow-up appointment to determine if there has been any irreversible brain damage or psychiatric issues?

Mi Li, 20~29 year old female. Ask Date: 2016/07/09

Dr. Zhan Jiaxiang reply Psychiatry


Hello, 米粒: For patients who have been using (meth)amphetamine long-term and frequently, withdrawal symptoms are quite common, and the duration of these symptoms may last up to 3 to 4 weeks.
Depression, anxiety, and irritability are symptoms that can easily occur during the withdrawal period.
Additionally, it is important to monitor for any co-occurring mental health disorders, such as depression or anxiety disorders, which require active management and treatment simultaneously.
It is recommended to continue encouraging family members to attend regular follow-up appointments and to discuss any observed phenomena with the physician.
Generally, through pharmacological and psychological interventions, issues related to amphetamine abuse can often see significant improvement.
Furthermore, specialized brain imaging may not always be clinically necessary; however, if the patient continues to exhibit cognitive dysfunction or other specific symptoms, the physician may arrange for testing based on the clinical situation.

Reply Date: 2016/07/09

More Info


Amphetamine abuse is a serious issue that can lead to a variety of mental health concerns, including anger management problems, mood swings, and potential long-term neurological effects. Your husband's situation, characterized by uncontrollable anger and irritability, is not uncommon among individuals who have been using amphetamines for an extended period. The fact that he has been using amphetamines for 2-3 years raises concerns about the potential impact on his brain and overall mental health.

Firstly, it's important to understand that amphetamines are central nervous system stimulants that can significantly alter mood and behavior. Chronic use can lead to changes in brain chemistry, particularly in areas that regulate emotions and impulse control. While your husband may not be experiencing hallucinations or delusions, his anger and irritability could be indicative of underlying changes in his brain function due to prolonged substance use.
The withdrawal symptoms from amphetamines can vary widely among individuals and may include fatigue, depression, increased appetite, and irritability. The fact that your husband has been off amphetamines for two weeks and is still experiencing significant anger issues suggests that he may be going through a challenging withdrawal phase. It's not unusual for irritability and mood swings to persist for weeks or even months after cessation, as the brain gradually readjusts to functioning without the drug.

Regarding the medications prescribed by his doctor, it’s common for healthcare providers to prescribe sedatives or anxiolytics to help manage withdrawal symptoms and stabilize mood. However, these medications can sometimes lead to increased drowsiness or sedation, which may not address the underlying issues of anger and irritability. It’s crucial for your husband to communicate openly with his healthcare provider about his experiences with the medication, as adjustments may be necessary to find the right balance for his treatment.

As for the duration of treatment and when to expect improvements, this can vary significantly based on individual factors such as the extent of amphetamine use, overall health, and adherence to the treatment plan. Typically, it may take several weeks to months for mood and behavior to stabilize after stopping amphetamines. Continuous follow-up with his healthcare provider is essential to monitor progress and make any necessary adjustments to his treatment plan.

Regarding your concern about potential brain damage or irreversible mental health issues, it is reasonable to discuss this with his doctor. While not all individuals who abuse amphetamines will experience permanent damage, some may have lasting effects on their cognitive and emotional functioning. Brain imaging studies, such as an MRI or CT scan, can provide insights into any structural changes in the brain, but these are typically reserved for cases where there are significant concerns about neurological damage.

In summary, your husband’s anger and irritability are likely linked to his history of amphetamine use and withdrawal. It is essential for him to continue working closely with his healthcare provider to manage these symptoms effectively. Open communication about his experiences with medications and any ongoing concerns about his mental health will be crucial in finding the right treatment approach. Additionally, discussing the possibility of brain imaging can help address concerns about potential long-term effects of his substance use. Support from family and friends, along with professional treatment, will be vital in his recovery journey.

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