Chronic Cough: Exploring Causes Beyond Allergies and Infections - Pulmonology

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Tracheal and bronchial foreign bodies


Hello, doctor.
I had a cold at the beginning of April, and while the symptoms of the cold have resolved, I have been experiencing a persistent cough for over three months now.
The previous cold symptoms are gone, but I feel an itchiness in my airways that triggers the urge to cough.
The cough is dry, with little to no phlegm, and when there is phlegm, it is clear and colorless, with a bit of foam.

So far, I have undergone several tests: 1.
Chest X-rays (I had them done at two different hospitals, and both doctors said there were no issues and nothing unusual was found).
2.
Pulmonary function tests, which were normal.
3.
Auscultation by about eight hundred doctors, all of whom found nothing wrong.
4.
I have taken medication for mycoplasma, but it was ineffective (I have also tried medications for post-nasal drip, bronchodilators, and cough suppressants).
5.
I had allergy blood tests, which showed high levels (4 out of 4) for cat dander, dust mites, and dust (I have taken numerous allergy medications, but they have not helped).
6.
I self-paid for a low-dose CT scan yesterday, and the report is not yet available.
7.
I underwent an endoscopy, and the doctor said there was nothing concerning.
I heard about a news story regarding an elderly man who had a chronic cough, and after one to two years of examinations that indicated bronchitis, it was eventually discovered that he had a foreign body lodged in his airway, which was only identified after a bronchoscopy when one of his lungs had collapsed.
This news prompted me to consider getting a CT scan.

Doctor, I would like to ask if a foreign body in the airway could cause a cough, and whether the X-rays and low-dose CT scan I have had can completely rule out these possibilities.
I am very concerned about the potential for a foreign body or lung cancer since I have tried various medications without success.
Could you please review the tests I have undergone and my symptoms and provide me with some advice? My current symptoms include airway itchiness, occasional discomfort in my chest (sometimes I feel an itch in the middle of my chest), and sometimes a sensation of a foreign body in my throat, which comes and goes.
The primary cause of my cough is the itchiness in my airways, which is very uncomfortable.
Most doctors I have seen say that I have an allergic cough.

Dino, 20~29 year old female. Ask Date: 2016/07/13

Dr. Huang Yiwen reply Pulmonology


DEAR DINO: After undergoing numerous tests and seeing various doctors, the only issue identified is an allergy.
Additionally, the results from the 64-slice CT scan have not yet come in, which may require further examination of IgE and eosinophil levels.
If the environmental conditions do not improve, medication may not be effective.
Improving your surrounding environment might help.
Changhua Hospital is concerned about you.

Reply Date: 2016/07/13

More Info


Chronic cough can be a perplexing and frustrating condition, especially when it persists long after other symptoms of an upper respiratory infection have resolved. In your case, it seems that you have been experiencing a dry cough for over three months following a cold, and despite numerous medical evaluations and treatments, the cough remains unresolved. This situation raises several important considerations regarding potential underlying causes and appropriate management strategies.

Firstly, it is essential to recognize that chronic cough can arise from a variety of factors beyond allergies and infections. While allergies to common allergens such as dust mites, pet dander, and mold can certainly contribute to respiratory symptoms, your extensive testing has not yielded significant improvements with antihistamines or other allergy medications. This suggests that other mechanisms may be at play.

One potential cause of your chronic cough could be postnasal drip, which occurs when mucus from the nasal passages drips down the back of the throat, irritating the cough receptors. This can happen even in the absence of noticeable nasal symptoms, particularly if you have a history of allergic rhinitis. It may be worthwhile to consider treatments specifically targeting postnasal drip, such as nasal corticosteroids or saline nasal rinses.

Another possibility is gastroesophageal reflux disease (GERD), which can cause chronic cough due to acid irritating the esophagus and throat. Even if your endoscopy did not reveal significant abnormalities, GERD can still be present and contribute to respiratory symptoms. A trial of proton pump inhibitors (PPIs) or lifestyle modifications (such as dietary changes and elevating the head during sleep) may provide relief.

Additionally, your symptoms could be indicative of a condition known as cough variant asthma. This form of asthma is characterized primarily by a chronic cough without the typical wheezing or shortness of breath. Given your history of allergies and the persistent nature of your cough, it may be beneficial to undergo further evaluation for asthma, including a methacholine challenge test or a trial of bronchodilators to see if there is any improvement in your symptoms.

Regarding your concerns about the possibility of an obstruction or malignancy, it is important to note that both X-rays and low-dose CT scans are generally effective in identifying significant abnormalities, including foreign bodies or tumors. However, small lesions or early-stage cancers may not always be visible. If your symptoms persist and you remain concerned, discussing the option of a bronchoscopy with your healthcare provider could be a reasonable next step. This procedure allows direct visualization of the airways and can help identify any obstructions or abnormalities that may not be apparent on imaging studies.

In summary, while your symptoms are suggestive of an allergic or irritant-induced cough, it is crucial to consider other potential causes such as postnasal drip, GERD, or cough variant asthma. Continued collaboration with your healthcare providers, including possibly seeking a referral to a pulmonologist or an allergist, may help in identifying the underlying cause of your chronic cough and developing an effective treatment plan. It is also essential to maintain open communication with your doctors about your ongoing symptoms and concerns, as this will facilitate a more tailored approach to your care.

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