Is Desoximetasone Safe for Pregnant Women with Eczema? - Obstetrics and Gynecology

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Dermatological medications


Hello, Doctor.
I am currently about 15 weeks pregnant.
I have been experiencing itching and flaking on my ears, so I visited a dermatologist who diagnosed me with eczema.
The doctor prescribed Desoximetasone cream 0.25%, with a composition of 2.5 mg, and advised me to apply it for a full month.
I looked up this ingredient online and it seems to be a corticosteroid, which makes me a bit concerned.
I would like to ask if this medication is safe for pregnant women to use, and whether using it for a month could have any effects on the fetus.
Thank you for your patient response.

Niming, 30~39 year old female. Ask Date: 2016/07/15

Dr. Lü Lizheng reply Obstetrics and Gynecology


The medication has minimal adverse effects on the fetus.
This is primarily because it is absorbed through the skin, resulting in low levels of the drug in the body.
Of course, if the duration of use can be reduced, it would be advisable to do so.
Sincerely, Dr.
Lu Li-Cheng, Taoyuan Hospital.

Reply Date: 2016/07/15

More Info


Desoximetasone is a topical corticosteroid that is often prescribed for inflammatory skin conditions, including eczema. When it comes to its use during pregnancy, it's essential to consider both the benefits and potential risks associated with corticosteroid use.

The safety of using Desoximetasone during pregnancy is not entirely straightforward. According to the FDA, topical corticosteroids are classified into different categories based on their potency and the potential risk they pose to the fetus. Desoximetasone is considered a medium-potency corticosteroid. While there is limited data on its specific effects during pregnancy, studies on other topical corticosteroids suggest that when used in moderation and for short durations, they may not pose significant risks to the developing fetus.

However, it is crucial to follow the guidance of your healthcare provider. The doctor who prescribed Desoximetasone likely weighed the benefits of treating your eczema against any potential risks. Eczema can cause significant discomfort, and untreated skin conditions can lead to increased stress and anxiety, which may also affect pregnancy. Therefore, managing your eczema effectively is important for both your well-being and that of your baby.

When using Desoximetasone, here are some important considerations:
1. Application: Apply the medication only to the affected areas and avoid using it on large surface areas of the body. This minimizes systemic absorption, which is particularly important during pregnancy.

2. Duration of Use: Your doctor has recommended using it for a month. If you have concerns about this duration, discuss them with your healthcare provider. They may be able to adjust the treatment plan based on your response to the medication and any side effects you may experience.

3. Monitoring: Keep an eye on any changes in your skin condition and report them to your doctor. If you notice any adverse effects or if your eczema worsens, it may be necessary to reassess your treatment plan.

4. Alternative Treatments: If you are uncomfortable using Desoximetasone, ask your doctor about alternative treatments. There are non-steroidal options available for managing eczema that may be safer during pregnancy.

5. Consultation: Always consult with your healthcare provider before starting or stopping any medication during pregnancy. They can provide personalized advice based on your medical history and the specifics of your pregnancy.

In summary, while Desoximetasone is a corticosteroid and carries some risks, its use in moderation under the guidance of a healthcare provider is generally considered acceptable for managing eczema during pregnancy. The key is to ensure that the benefits of treating your condition outweigh any potential risks to your baby. Always prioritize open communication with your healthcare team to ensure the best outcomes for both you and your child.

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