Impact of High Doses of Sleep Aids on Fetal Development - Obstetrics and Gynecology

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Ingested a large amount of sleeping pills?


Hello Doctor, I am currently 14 weeks pregnant.
Due to severe morning sickness, I accidentally discovered that taking Sitalopram can alleviate my stomach discomfort.
Since around the 5th to 6th week, I have been taking about 5-7 tablets of Sitalopram daily to manage my stomach pain.
However, I am very concerned whether this high dosage will affect my baby's development and brain intelligence.

Ting Li, 30~39 year old female. Ask Date: 2016/08/25

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, the level used by Tinos is C, which theoretically has little impact.
If you still have concerns, you may consult your regular obstetrician-gynecologist.
Wishing you good health.

Reply Date: 2016/08/25

More Info


The use of sleep aids during pregnancy, particularly in high doses, raises significant concerns regarding fetal development. In your case, you mentioned taking a medication called "Stilnox" (also known as Zolpidem) in excessive amounts to alleviate severe nausea and discomfort associated with early pregnancy. While it is understandable that you are seeking relief from these distressing symptoms, it is crucial to consider the potential implications for your developing baby.

Stilnox is classified as a Category C medication by the FDA, which means that while animal studies have shown some adverse effects on the fetus, there are no well-controlled studies in pregnant women. This classification indicates that the drug should only be used if the potential benefits justify the potential risks to the fetus. High doses of sleep aids can lead to various complications, including potential effects on fetal brain development and overall health.

Research has shown that excessive use of sedative-hypnotics during pregnancy may be associated with an increased risk of developmental delays, behavioral issues, and cognitive impairments in children. The central nervous system of a developing fetus is particularly sensitive to external substances, and exposure to high doses of sleep medications may interfere with normal neurodevelopment. This interference can manifest as difficulties in attention, learning, and memory as the child grows.

Moreover, the use of sleep aids can also lead to complications such as respiratory depression in the newborn, especially if the mother takes these medications close to the time of delivery. This condition can result in decreased oxygen levels and may require medical intervention for the newborn.

Given your situation, it is essential to consult with your obstetrician or a maternal-fetal medicine specialist. They can provide personalized guidance based on your medical history and the specifics of your pregnancy. It may be necessary to explore alternative methods for managing nausea and sleep disturbances that do not involve high doses of medication. Non-pharmacological approaches, such as dietary changes, acupuncture, or cognitive-behavioral therapy, may offer relief without the associated risks of medication.

In addition, maintaining good sleep hygiene practices can help improve your sleep quality. This includes establishing a regular sleep schedule, creating a comfortable sleep environment, and avoiding stimulants like caffeine close to bedtime. Engaging in relaxation techniques, such as deep breathing exercises or prenatal yoga, can also promote better sleep and reduce anxiety.

In summary, while Stilnox may provide temporary relief from nausea and sleep disturbances, its excessive use during pregnancy poses potential risks to fetal development. It is crucial to work closely with your healthcare provider to find safer alternatives and ensure the well-being of both you and your baby. Prioritizing open communication with your medical team will help you navigate this challenging time and make informed decisions regarding your health and the health of your developing child.

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