Consultation on Drug Interactions for Stomach Ulcer Treatment - Pharmacology

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Consultation on Drug Interactions for Peptic Ulcer Medications


Hello, I was recently diagnosed with a gastric ulcer and gastroesophageal reflux disease (GERD).
I am currently taking one tablet of Pantoprazole daily and have not yet started treatment for Helicobacter pylori.
A few days ago, I injured my throat with a fish bone, causing ulceration and inflammation, and I also have some cold symptoms (coughing with phlegm).
I visited an ENT specialist who prescribed the following medications: 1.
UCLOR 250MG 2.
PURFEN F.C.
TABLET 3.
SWEICON TABLETS 4.
LYSOZYME 5.
Xyzalin 6.
SICOTAN CAPSULES 7.
FRANDYL 8.
LIQUID BROWN MISTU.
I only know that UCLOR is an antibiotic, and I have been taking it for three days.
The medications listed above were prescribed during my follow-up visit today.

I would like to ask:
1.
As far as I know, antibiotics can be very harsh on the stomach, and I am worried that continuing to take them will worsen my gastric ulcer.
Currently, my throat injury has improved but is not fully healed.
Should I continue taking the antibiotic or stop it to allow my throat to heal on its own? How many days should I take this antibiotic at a minimum?
2.
Are the other medications listed also harsh on the stomach and could they exacerbate my gastric ulcer? I am very concerned that my gastric ulcer, which has stabilized somewhat, might flare up again! Additionally, I have a trip abroad next week.

P.S.
I informed the doctor about my gastric ulcer when the medications were prescribed, and the doctor reassured me that it would be fine, which has left me quite worried.
I would appreciate any advice and guidance from the pharmacist.
Thank you!

JY, 20~29 year old female. Ask Date: 2016/09/02

Dr. Hou Fangmin reply Pharmacology


Hello: The medications you are taking are antibiotics for inflammation, pain relief, stomach medications, and enzymes.
Having a simple medication for a runny nose is fine for short-term use and should not cause a gastric ulcer.
Antibiotics should be taken for at least 7 days.
I apologize for not seeing your message as it ended up in the spam folder.
I'm very sorry.

Reply Date: 2016/09/02

More Info


When dealing with a diagnosis of stomach ulcers and gastroesophageal reflux disease (GERD), it is crucial to understand the medications prescribed and their potential interactions, especially when additional medications are introduced for other health issues, such as throat ulcers or infections.

1. Antibiotics and Stomach Ulcers: You mentioned that you are currently taking UCLOR, which is an antibiotic. While it is true that some antibiotics can irritate the stomach lining, it is also important to recognize that antibiotics are often necessary to treat infections effectively. If your throat ulcer is due to a bacterial infection, continuing the antibiotic may be essential for your recovery. Generally, antibiotics should be taken for a prescribed duration, often around 7 to 10 days, depending on the specific infection being treated. Stopping an antibiotic prematurely can lead to incomplete treatment and antibiotic resistance.

2. Concerns about Gastric Irritation: You expressed concern about the potential for antibiotics to exacerbate your stomach ulcer. While some antibiotics can cause gastrointestinal upset, the risk of worsening a stomach ulcer largely depends on the specific antibiotic and the individual’s overall health. UCLOR (likely amoxicillin or a similar antibiotic) is not typically known for causing significant gastric irritation compared to other medications. However, if you experience increased pain or discomfort, it is essential to communicate this with your healthcare provider. They may adjust your treatment plan or suggest protective medications, such as proton pump inhibitors (PPIs) or H2 blockers, to help mitigate gastric irritation.

3. Other Medications: You listed several other medications, including PURFEN (a pain reliever), SWEICON (an antacid), LYSOZYME (an enzyme), Xyzalin (an antihistamine), SICOTAN (a combination medication), FRANDYL (an anti-anxiety medication), and LIQUID BROWN MISTU (likely a cough syrup). Among these, PURFEN, which is likely a non-steroidal anti-inflammatory drug (NSAID), can indeed irritate the stomach lining and should be used cautiously in individuals with a history of ulcers. If you need pain relief, consider discussing alternatives with your doctor that are less likely to cause gastric irritation.

4. Managing Your Health: Given your concerns about the interactions and effects of these medications on your stomach ulcer, it is advisable to maintain open communication with your healthcare provider. They can provide tailored advice based on your specific situation, including whether to continue the antibiotic or adjust any other medications. Additionally, lifestyle modifications such as avoiding spicy foods, caffeine, and alcohol, as well as managing stress, can significantly aid in the healing process of ulcers.

5. Travel Considerations: Since you mentioned upcoming travel, it is crucial to ensure that your treatment plan is stable before you go. Discuss with your doctor any potential changes in your medication regimen that may be necessary while you are away. Carrying a sufficient supply of your medications and having a plan for managing any potential flare-ups during your trip is also essential.

In conclusion, while antibiotics can pose some risk of gastric irritation, they are often necessary for treating infections. It is vital to follow your healthcare provider's recommendations, monitor your symptoms closely, and communicate any concerns you have regarding your medications. This proactive approach will help ensure that your stomach ulcer remains stable while effectively treating your throat condition.

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