Thyroid Papillary Cancer: Total vs. Partial Removal Options Explained - Oncology

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Total or partial thyroidectomy for papillary thyroid carcinoma?


Hello, Director Lai.
I am a 38-year-old female.
In July of this year, a health check revealed a suspected tumor larger than 3 cm on the left side of my thyroid.
I was referred to a larger hospital for blood tests and a thyroid biopsy, which confirmed a diagnosis of stage I papillary thyroid carcinoma, with an encapsulated tumor of approximately 2 cm and no lymph node metastasis.
I have consulted three doctors; one recommended total thyroidectomy followed by radioactive iodine treatment to prevent recurrence, while another suggested simply removing the left-sided lesion and monitoring it afterward.
I would like to ask if you recommend just removing the left-sided lesion and then monitoring it?

Niu, 30~39 year old female. Ask Date: 2016/09/23

Dr. Lai Yicheng reply Oncology


Hello, Miss Niu.

1.
Surgery is typically the first step in treating thyroid cancer, aiming to remove as much cancerous tissue as possible.
In rare cases of localized and well-differentiated thyroid cancer, a unilateral lobectomy may be considered; however, most patients should undergo total thyroidectomy.
After total thyroidectomy, patients will receive a moderate dose of iodine-131 a few weeks later to eliminate any remaining thyroid tissue (both benign and malignant).
Subsequently, a whole-body iodine-131 scan will be scheduled to check for any residual thyroid tissue or malignant tumors (at this point, normal residual thyroid tissue can often be visualized in the neck).
After the scan, patients can begin daily oral thyroid hormone replacement to gradually restore thyroid function and exert a tumor-suppressing effect; thyroid hormone must be taken for life.
For patients with lymphatic metastasis or local recurrence, surgery remains the best option.
2.
During follow-up, if a new mass is discovered, fine-needle aspiration cytology remains the best method for examination.
After surgery and radioactive iodine treatment, thyroid function and thyroglobulin levels should be checked every three to six months to adjust the dosage of thyroid hormone and monitor for recurrence.
Additionally, patients should have a chest X-ray annually to check for pulmonary metastasis.
Due to the risk of osteoporosis from excessive thyroid hormone supplementation, female patients should have their bone density checked annually.
Approximately every year, patients should stop taking thyroid hormone for one month and undergo a whole-body iodine-131 scan to detect any recurrence.
Bone scans and computed tomography may also be used when necessary.
In certain cases, positron emission tomography (PET) can also detect sites of recurrence.
Changhua Hospital cares about you.
Thank you for your consultation.
Department of Radiation Oncology, Dr.
Lai Yi-Cheng.

Reply Date: 2016/09/23

More Info


When it comes to managing thyroid papillary cancer, particularly in your case where the tumor is diagnosed at an early stage (Stage I) and has not shown any lymph node metastasis, the decision between total thyroidectomy and partial thyroidectomy (hemithyroidectomy) is a nuanced one that requires careful consideration of various factors.

Total Thyroidectomy vs. Partial Thyroidectomy:
1. Total Thyroidectomy: This involves the complete removal of the thyroid gland. It is often recommended for patients with larger tumors, multifocal disease, or those with a higher risk of recurrence. The rationale behind total thyroidectomy is to minimize the risk of residual cancer and the potential for recurrence. Additionally, after total thyroidectomy, patients typically undergo radioactive iodine (RAI) therapy, which can help eliminate any remaining thyroid cancer cells. This approach is particularly beneficial in younger patients and those with aggressive tumor features.

2. Partial Thyroidectomy (Hemithyroidectomy): This option involves removing only the affected lobe of the thyroid gland. It is often considered for smaller tumors (usually less than 1-2 cm) that are well-differentiated and have no evidence of metastasis. The advantages of this approach include preserving some thyroid function, which may reduce the need for lifelong thyroid hormone replacement therapy. However, there is a risk of recurrence in the remaining thyroid tissue, and careful monitoring is required.

Factors to Consider:
- Tumor Size and Characteristics: Your tumor is approximately 2 cm, which is on the borderline for considering total versus partial removal. The characteristics of the tumor, such as its histological features and whether it exhibits aggressive behavior, are crucial in making this decision.

- Patient Age and Health: At 38 years old, you are relatively young, and your overall health status can influence the surgical decision. Younger patients tend to have better outcomes with total thyroidectomy due to the lower risk of complications and better long-term monitoring.

- Surgeon's Experience and Recommendations: The opinions of the three different surgeons you consulted reflect the variability in practice patterns. It is essential to consider their experience and the protocols they follow. Surgeons with extensive experience in thyroid cancer management may lean towards total thyroidectomy for better long-term outcomes.

- Follow-Up and Monitoring: If you opt for a partial thyroidectomy, regular follow-up with ultrasound and serum thyroglobulin levels will be necessary to monitor for recurrence. If any suspicious findings arise, further intervention may be required.

Conclusion:
In summary, while both total and partial thyroidectomy have their merits, the decision should be tailored to your specific situation. Given that your tumor is 2 cm and has not metastasized, a partial thyroidectomy may be a reasonable option, especially if the tumor exhibits favorable characteristics. However, if there are concerns about the tumor's behavior or if you prefer a more aggressive approach to minimize recurrence risk, total thyroidectomy followed by RAI therapy could be the better choice.

Ultimately, it is crucial to have an in-depth discussion with your healthcare provider, considering all the factors mentioned above, to arrive at a decision that aligns with your preferences and medical needs. Regular follow-up and monitoring will be essential regardless of the surgical approach chosen.

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