Benign Fasciculation Syndrome: Causes and Treatment Options - Neurology

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Involuntary twitching of the eyelids and body muscles?


In early July, my left upper eyelid suddenly started to twitch involuntarily.
At first, I thought it was due to eye fatigue and didn't pay much attention to it.
However, the frequency of the twitches increased, and I began to notice more occurrences.
I consulted both an ophthalmologist and a traditional Chinese medicine practitioner, but there was no improvement.
I then started seeing a neurologist, who prescribed me vitamin E, suggesting that it might be facial spasms and that vitamin E could be beneficial for the nerves.
Initially, I thought it was just a simple spasm, but after a few days of taking the medication, my condition worsened! It escalated to involuntary twitching of my entire body and my left upper eyelid.
During this time, due to worry and anxiety, I visited several different neurologists.
I had blood tests for muscle enzymes and thyroid function, but all reports were within normal ranges.
However, the doctors indicated that my symptoms did not involve weakness or atrophy, advising me not to worry and that an electromyography (EMG) was unnecessary to avoid unnecessary discomfort, suggesting I just relax.
Nevertheless, the unknown cause of my symptoms was quite distressing, and I even experienced twitching during sleep, which severely affected my sleep and daily life.
I realized that delaying further would only increase my anxiety, so I sought an appointment at a large hospital with the head of the neurology department.
The doctor was very patient and listened attentively to my symptoms and concerns, unlike previous doctors who dismissed my worries after just a few comments, which was quite frustrating.
The neurologist also arranged for nerve conduction studies and an EMG, and finally, the reports came back today! They indicated that everything was normal, ruling out conditions like muscular dystrophy or amyotrophic lateral sclerosis (ALS), which relieved me.
However, the doctor mentioned that my symptoms are actually referred to as Benign Fasciculation Syndrome.
I would like to ask, what could be the causes of this condition? My current doctor has prescribed Clonazepam 0.5 mg, which can help with seizures, sleep, and anxiety.
Will taking this medication for a while truly improve my current symptoms?

Xiao Lin, 20~29 year old female. Ask Date: 2016/09/29

Dr. Gao Chunde reply Neurology


The reasons are as you described: tension and stress, sometimes due to lack of sleep.
The examination will not show any abnormalities; it is the nerves that are more excitable due to the aforementioned conditions.
Your medication can help improve this.
Additionally, maintaining a regular routine and engaging in outdoor activities to relax your mind and body will also be beneficial.

Reply Date: 2016/09/29

More Info


Benign Fasciculation Syndrome (BFS) is a neurological condition characterized by involuntary muscle twitches or fasciculations, which can occur in various parts of the body, including the eyelids, arms, and legs. While the exact cause of BFS is not fully understood, it is often associated with factors such as stress, anxiety, fatigue, and sometimes electrolyte imbalances. In many cases, BFS is considered a benign condition, meaning it is not associated with serious underlying diseases like amyotrophic lateral sclerosis (ALS) or other neurodegenerative disorders, which can cause similar symptoms.

Your experience with the sudden onset of eyelid twitching, which then progressed to more widespread muscle twitching, is not uncommon in BFS. The initial twitching may have been triggered by stress or fatigue, and the subsequent increase in symptoms could be related to heightened anxiety about your condition. It’s important to note that anxiety can exacerbate physical symptoms, leading to a cycle of worry and increased muscle tension.

The treatment for BFS often focuses on symptom management and addressing any underlying anxiety or stress. Clonazepam, which you have been prescribed, is a benzodiazepine that can help reduce anxiety and promote relaxation. It is also effective in managing muscle spasms and can help improve sleep quality, which is often disrupted in individuals experiencing twitching. While clonazepam may not directly eliminate the fasciculations, it can help alleviate anxiety and muscle tension, potentially leading to a reduction in the frequency and intensity of the twitches over time.

In addition to medication, there are several lifestyle modifications and complementary approaches that may help manage BFS symptoms:
1. Stress Management: Techniques such as mindfulness, meditation, and yoga can be beneficial in reducing stress and anxiety levels. Engaging in regular physical activity can also help improve overall well-being and reduce muscle tension.

2. Sleep Hygiene: Ensuring you have a regular sleep schedule and creating a restful sleep environment can help improve sleep quality, which may reduce twitching episodes.

3. Diet and Hydration: Maintaining a balanced diet rich in vitamins and minerals, particularly magnesium and potassium, can support muscle function. Staying well-hydrated is also important, as dehydration can contribute to muscle cramps and spasms.

4. Avoiding Stimulants: Reducing or eliminating caffeine and other stimulants can help minimize muscle twitching, as these substances can increase nervous system excitability.

5. Physical Therapy: If muscle tension is a significant issue, working with a physical therapist may help you learn relaxation techniques and exercises to reduce muscle tightness.

As for the duration of clonazepam treatment, it is essential to have ongoing discussions with your healthcare provider. While some individuals may find relief with short-term use, others may require a longer duration of treatment. Your doctor will monitor your symptoms and may adjust your medication as needed to ensure optimal management of your condition.

In summary, while BFS can be distressing, it is generally a benign condition that can be managed effectively with a combination of medication, lifestyle changes, and stress management techniques. It is crucial to maintain open communication with your healthcare provider to address any concerns and adjust your treatment plan as necessary. If symptoms persist or worsen, further evaluation may be warranted to rule out other potential causes.

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