Breast Issues: Alternatives to Biopsy for Papilloma Evaluation - Breast and Thyroid

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Breast issues


Recently, I discovered that I could express a clear discharge from my nipple during a self-examination.
I went to the hospital for an evaluation, and the doctor informed me that it was papillomary cells due to a papilloma.
I need to undergo a minor surgery to remove part of the milk duct for examination.
Three months ago, I had a mastectomy and had a tissue expander implanted.
The original doctor recommended an MRI, but it is not applicable due to the metal components in the expander.
Aside from surgical biopsy, are there any other tests that can determine the presence of cancer cells? I have already lost sensation and lactation function on one side.

Linlin, 20~29 year old female. Ask Date: 2016/10/05

Dr. Wu Jianting reply Breast and Thyroid


Regarding papilloma cells, surgery not only serves to examine and diagnose but also has a therapeutic role, as papillomas have a higher tendency to grow or recur.
Surgical excision can be considered; however, if there are concerns due to previous surgeries, regular ultrasound follow-ups every three months may also be considered.
Thank you for your question.

Reply Date: 2016/10/05

More Info


When dealing with breast health issues, particularly concerning the presence of papilloma and associated symptoms such as transparent nipple discharge, it is crucial to approach the situation with a comprehensive understanding of the diagnostic options available. Given your recent history of breast surgery and the presence of a tissue expander, it is understandable that you are seeking alternatives to a biopsy for evaluating the potential presence of cancer cells.

Papillomas are benign tumors that can develop in the ducts of the breast and may lead to symptoms such as discharge. While a biopsy is often the gold standard for diagnosing any suspicious lesions, there are several other diagnostic modalities that can be considered, especially when traditional imaging techniques like MRI are not feasible due to the presence of metal components in a tissue expander.

1. Ultrasound: This is a non-invasive imaging technique that can be particularly useful in evaluating breast tissue. It can help differentiate between solid masses and fluid-filled cysts and can guide further management. Regular follow-up ultrasounds, as suggested, can be beneficial in monitoring any changes in the breast tissue over time.

2. Mammography: While mammograms are typically used for routine screening, they can also be helpful in evaluating specific areas of concern in the breast. If you have not had a recent mammogram, it may be worth discussing this option with your healthcare provider.

3. Fine Needle Aspiration (FNA): This is a minimally invasive procedure where a thin needle is used to extract cells from a suspicious area for cytological examination. While it may not provide a definitive diagnosis like a core biopsy, it can help in assessing whether there are any malignant cells present.

4. Ductography: If the discharge is coming from a specific duct, ductography (a specialized X-ray of the milk ducts) can be performed. This involves injecting a contrast material into the duct to visualize it on X-ray, which can help identify any abnormalities.

5. Clinical Examination: Regular follow-ups with your healthcare provider for clinical breast examinations are essential. They can assess any changes in the breast tissue and provide guidance on further steps based on clinical findings.

6. Genetic Testing: If there is a significant family history of breast cancer or other risk factors, genetic counseling and testing may be appropriate. This can help assess your risk for developing breast cancer and guide management decisions.

7. Monitoring Symptoms: Keeping track of any changes in symptoms, such as the nature of the discharge, any new lumps, or changes in breast shape or size, is crucial. This information can be valuable for your healthcare provider in determining the next steps.

It is important to maintain open communication with your healthcare team. Given your previous surgery and the complexities involved, they can tailor a diagnostic approach that considers your unique situation. While the fear of cancer is understandably distressing, many breast conditions are benign and manageable. Regular monitoring and appropriate imaging can provide reassurance and help in early detection if any changes occur.

In conclusion, while a biopsy is often necessary for definitive diagnosis, there are several alternative diagnostic methods available that can help evaluate breast health and the presence of potential malignancies. Discuss these options with your healthcare provider to determine the best course of action for your specific circumstances.

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