Endocrine Issues and PCOS in Young Women: A Case Study - Internal Medicine

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Regarding Endocrinology and Polycystic Ovary Syndrome (PCOS)


Hello, Doctor: I am currently 19 years old, with a height of 151 cm, weight of 45.4 kg, body fat percentage of 20.3%, and a waist circumference of 58 cm.
Description of my condition: In March of this year, my weight suddenly increased from a stable 48 kg to 52 kg, and I missed my period for two months, during which I developed a lot of acne.
After an ultrasound examination (without blood tests), the gynecologist diagnosed me with polycystic ovary syndrome (PCOS) related to endocrine issues and advised me to exercise more and eat healthy foods, but did not prescribe any medication.
After following this advice, my menstrual cycle returned to normal, and I successfully lost weight.
The acne improved with antibiotics, but I still have excessive body hair.
At the school health center, my body fat and waist circumference were measured as normal, but my basal metabolic rate is only 1092 kcal, which is below average.
Could you please explain why this is the case? Additionally, during a health check-up a year ago, I was found to have high cholesterol (marked in red).
Is my condition suitable for consultation with an endocrinologist or a metabolic specialist? Thank you for your guidance!

Ni Ni, 10~19 year old female. Ask Date: 2016/10/09

Dr. Xiao Yongxun reply Internal Medicine


Dear Miss Nini:
1.
The formula for Basal Metabolic Rate (BMR) is often estimated using various regression equations; it represents the energy required to maintain basic physiological functions daily.
It can be used as a reference, but there is no need to be overly concerned, as it represents an estimate and differs from more precise and time-consuming laboratory tests.
2.
Your obstetrician-gynecologist diagnosed you with Polycystic Ovary Syndrome (PCOS) via ultrasound and informed you that it is related to endocrine issues, recommending increased physical activity and a healthy diet without prescribing medication.
I personally believe he is an excellent and knowledgeable physician.
In medicine, treatment is not solely reliant on medication.
Given your situation and age, his approach is undoubtedly successful.
PCOS is often associated with insulin resistance, which can lead to secondary diabetes, as well as acne, increased body hair, and infertility.
Weight loss and avoiding refined, high-fat, low-nutrient diets and processed foods (such as beverages, refined pastries, takeout, and convenience store foods) are preliminary yet effective methods.
If improvement is still not observed, then medication intervention should be considered.
3.
If your cholesterol levels are elevated, dietary and exercise modifications should be the first approach.
It is advisable to reduce the intake of high-cholesterol and trans fats (commonly found in creamers, butter, ghee, instant coffee mixes, milk tea, etc.) and high fructose corn syrup (often found in commercially available beverages, desserts, cola, pastries, etc.).
These types of foods may be harder for the body to metabolize, can be high in calories without providing satiety, and may also lead to increased blood sugar levels.
Additionally, increased physical activity can help lower cholesterol levels.
As for considering a visit to an endocrinologist, there is nothing wrong with that; it could be worth trying.
4.
From my understanding, the treatment of Polycystic Ovary Syndrome is primarily managed by obstetricians-gynecologists, as it involves many infertility issues, and there are indeed many related patients.

Reply Date: 2016/10/09

More Info


Understanding endocrine issues, particularly Polycystic Ovary Syndrome (PCOS), is crucial for young women experiencing symptoms like irregular menstruation, weight fluctuations, and skin issues such as acne. Your case presents a common scenario where hormonal imbalances manifest in various ways, and it’s important to address these concerns holistically.

At 19 years old, your sudden weight gain from 48 kg to 52 kg, coupled with missed periods and increased acne, aligns with the symptoms often associated with PCOS. PCOS is characterized by hormonal imbalances that can lead to irregular menstrual cycles, excess androgen levels, and polycystic ovaries, which may not always be visible on ultrasound. The fact that your gynecologist diagnosed you based on ultrasound findings without blood tests is not uncommon, as many practitioners rely on clinical symptoms and imaging to make an initial diagnosis.

The recommendation to adopt a healthier lifestyle through increased physical activity and a balanced diet is a standard approach for managing PCOS. Weight management can significantly improve insulin sensitivity, which is often impaired in women with PCOS. This can lead to more regular menstrual cycles and reduced symptoms such as acne and hirsutism (excessive hair growth). It’s encouraging to hear that you have successfully managed to regulate your menstrual cycle and lose weight by following these recommendations.

Regarding your concern about your basal metabolic rate (BMR) being lower than average, it’s important to understand that BMR can vary widely among individuals based on factors such as muscle mass, age, and hormonal levels. A BMR of 1092 kcal may indicate that your body requires less energy at rest, which can be influenced by your overall body composition and metabolic health. Engaging in regular exercise, particularly strength training, can help increase muscle mass and subsequently raise your BMR.

Your elevated cholesterol levels noted in previous health checks are also a concern, particularly in the context of PCOS, as women with this condition are at a higher risk for metabolic syndrome, which includes high cholesterol, insulin resistance, and obesity. Dietary changes, such as reducing saturated fats and increasing fiber intake, along with regular exercise, can help manage cholesterol levels effectively.

As for whether you should consult an endocrinologist or a metabolism specialist, it may be beneficial, especially if you continue to experience symptoms or if your cholesterol levels remain high despite lifestyle changes. An endocrinologist can provide a more comprehensive evaluation of your hormonal health, including potential insulin resistance, and may recommend further testing, such as blood work to assess hormone levels, glucose tolerance, and lipid profiles.

In summary, your situation reflects a common intersection of endocrine issues and lifestyle factors in young women. Continuing to focus on a healthy lifestyle, monitoring your symptoms, and seeking further medical advice when necessary will be key in managing your health effectively. Remember, PCOS is a manageable condition, and with the right support and interventions, many women successfully navigate its challenges.

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