Corneal Inflammation: Symptoms, Diagnosis, and Treatment Options - Ophthalmology

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The severity of keratitis is very unclear?


Hello, Doctor.
In mid-October this year, I mistakenly wore contact lenses that had been soaked in a contact lens case (with the solution being from Alcon) for six months.
The next day, my eyes were red and swollen, with conjunctival edema.
I experienced photophobia and blurred vision, along with a foreign body sensation.
I went to a clinic for treatment, but after three days with no improvement, I visited Kaohsiung Medical University Hospital.
The doctor diagnosed me with viral conjunctivitis and keratitis, prescribing five medications.
After two days of use, the swelling worsened, so I went to another clinic.
Initially, the doctor also said it was a viral infection, but after a few days with no improvement, I was switched to Systane eye drops, which were suggested for a possible microsporidial infection, with instructions to apply every two hours.
Today marks the fifth day of treatment, but my eyes are still very red and swollen, and I feel a swelling sensation in my eyeballs.
The distance between my eyelids has increased to three times the original size, and there are still punctate epithelial defects on the cornea.
I am extremely photophobic; yesterday, I could only look at the computer screen (which is set to the lowest brightness) for two minutes before I couldn't tolerate it anymore.
However, I do not have tearing; instead, I feel a bit of dry eye and a heavy foreign body sensation.
Today, I am not as photophobic as yesterday, but the other symptoms remain similar.

I would like to ask the doctor:
1.
Is it necessary to perform a corneal scraping to confirm the diagnosis?
2.
If it is indeed a microsporidial infection, I found online that it is a type of fungus, but the information for Systane states that it is targeted for bacterial infections.
Is this medication appropriate for my condition? I read online that patients with microsporidial infections were treated successfully with antibiotics and corneal micro-scraping.
Is surgery necessary in my case?
3.
My vision is extremely blurry; my original prescription was about -6.50 diopters.
I used to see the computer screen clearly from 50 cm away, but now I must be at 25 cm to see clearly, and it has worsened to needing about 15 cm to see clearly, yet it still appears foggy.
If I can maintain my current condition without further deterioration, will I be able to restore my original vision after recovery?
Thank you, Doctor, for taking the time to read and respond amidst your busy schedule.
:)

Rebecca, 30~39 year old female. Ask Date: 2016/10/29

Dr. Gao Pilin reply Ophthalmology


Hello Rebecca: Please do not delay seeking medical attention any longer.
If there is still no improvement, quickly return to the outpatient clinic at Kaohsiung Medical University Hospital.
If there is a cornea specialist available, please schedule an appointment with that physician.
Severe corneal infections can have permanent effects on vision.
Whether a corneal scraping is necessary will depend on the clinical presentation, and it may require microscopy or bacterial culture.
The ophthalmology department at Puzi Hospital in Taiwan is open Monday to Friday from 8:00 AM to 12:00 PM and Wednesday afternoons from 1:00 PM to 4:30 PM.
Online responses can only serve as a reference; it is essential to seek care at a medical facility if needed.
I hope to have the opportunity to assist you.
Dr.
Kao Pi-Lin

Reply Date: 2016/10/29

More Info


Corneal inflammation, often associated with conditions like viral conjunctivitis and keratitis, can lead to significant discomfort and visual impairment. Your symptoms of redness, swelling, photophobia (light sensitivity), and foreign body sensation are indicative of such inflammation. The fact that you experienced these symptoms after wearing contact lenses that had been improperly stored raises concerns about potential infections, including viral or parasitic infections.


Symptoms of Corneal Inflammation
Common symptoms of corneal inflammation include:
- Redness of the eye
- Swelling of the conjunctiva (the membrane covering the white part of the eye)
- Photophobia
- Blurred vision
- Foreign body sensation
- Tearing or dryness
In your case, the diagnosis of viral conjunctivitis and keratitis suggests that the inflammation is likely due to a viral infection, which can be exacerbated by the use of contaminated contact lenses.


Diagnosis
Diagnosis typically involves a thorough eye examination, including:
- Visual acuity tests
- Slit-lamp examination to assess the cornea and conjunctiva
- Fluorescein staining to identify corneal abrasions or ulcers
- Cultures or PCR tests to identify specific pathogens if a microbial infection is suspected.

In some cases, if the diagnosis remains unclear or if there is a suspicion of a more severe infection (like a microsporidian infection), further diagnostic procedures may be warranted.


Treatment Options
Treatment for corneal inflammation depends on the underlying cause:
1. Viral Infections: Antiviral medications may be prescribed if a viral infection is confirmed. Supportive care, including lubricating eye drops and cold compresses, can help alleviate symptoms.

2. Bacterial Infections: Antibiotic eye drops are typically used if a bacterial infection is suspected.

3. Parasitic Infections: If a microsporidian infection is confirmed, specific antifungal or antiparasitic treatments may be necessary. The use of medications like "Systane" (which you mentioned) may not be effective against such infections if they are primarily targeting bacteria.


Surgical Intervention
Regarding your questions about surgery:
1. Corneal Scraping: This procedure is sometimes necessary to obtain samples for culture and to confirm the presence of specific pathogens. It can also help in cases where there are corneal ulcers or significant damage.

2. Need for Surgery: If your condition does not improve with medical treatment and there is a confirmed diagnosis of a microsporidian infection, surgical intervention may be required. This could involve scraping the cornea or other procedures to remove infected tissue.

3. Vision Recovery: The prognosis for vision recovery after corneal inflammation largely depends on the extent of the damage to the cornea. If the inflammation is controlled and there is no significant scarring, many patients can regain their previous level of vision. However, persistent symptoms or complications may lead to long-term visual impairment.


Conclusion
It's crucial to follow up closely with your eye care provider, especially given the persistence of your symptoms and the potential for complications. If your condition does not improve or worsens, further evaluation and possibly a referral to a corneal specialist may be necessary. Maintaining good hygiene with contact lenses and seeking prompt treatment for any eye symptoms can help prevent such issues in the future.

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