Thyroid Tumors: Surgical Options and Lifelong Medication - Internal Medicine

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Thyroid tumor


Dear Director: At A Hospital, a biopsy was performed on both thyroid nodules, with the right side measuring 1.3 cm and the left side 0.85 cm.
The physician informed me that after total thyroidectomy, lifelong medication would be necessary.
At B Hospital, a biopsy showed a 1.2 cm nodule on the right side, with no nodules on the left, and only the right thyroid was removed.
The results from both hospitals are not entirely consistent, but both physicians indicated a suspicion of papillary thyroid carcinoma, necessitating removal followed by pathological examination for confirmation.

I would like to ask: 1.
Should I have the right side removed or both sides? 2.
If only the right side is removed, will there be issues with the left side in the future? I am very reluctant to take lifelong medication and am concerned about the impact on my physiological function.

Ping An, 50~59 year old female. Ask Date: 2016/11/02

Dr. Xiao Yongxun reply Internal Medicine


Dear Miss Ping An,
1.
Papillary carcinoma is the most common type of malignant thyroid tumor, predominantly occurring in young women.
It typically presents with an irregular shape, and the tumor cells are arranged in a papillary pattern.
Characteristic nuclear changes include ground-glass nuclei, nuclear membrane invaginations forming nuclear grooves, intranuclear inclusions, and nuclear overlapping.
The tumor often contains psammoma bodies.
It has a tendency to invade adjacent tissues and local lymph nodes, while distant metastasis is less common, and the overall prognosis is generally favorable.
2.
If the right side is surgically removed alone, there is certainly a possibility that papillary carcinoma may recur on the left side.
If both sides are removed, thyroid hormone replacement will be necessary to maintain normal metabolic function.
It is possible for the test results from two different hospitals to vary, and even reports from two specialists in the same subspecialty may differ.
Please be honest with your chosen attending physician and discuss your concerns and uncertainties with them.

Reply Date: 2016/11/02

More Info


When it comes to managing thyroid tumors, particularly in the case of suspected papillary thyroid carcinoma, the surgical options and the implications for lifelong medication are crucial considerations. Based on the information provided, it seems that you are facing a decision regarding whether to undergo a total thyroidectomy (removal of both lobes) or a partial thyroidectomy (removal of just one lobe).
1. Surgical Options: The choice between total thyroidectomy and lobectomy (removal of one lobe) largely depends on several factors, including the size of the tumors, their characteristics, and the presence of any suspicious features in the pathology reports. In your case, both hospitals have indicated the presence of nodules that may be indicative of papillary thyroid carcinoma. Generally, if there is a confirmed diagnosis of papillary thyroid carcinoma, especially if it is larger than 1 cm, a total thyroidectomy is often recommended. This is because papillary thyroid carcinoma can have multifocality (multiple tumors in the thyroid) and can recur if not completely removed.
If the tumor is small and there are no concerning features, a lobectomy may be sufficient. However, the decision should be made in consultation with an experienced endocrinologist or thyroid surgeon who can assess the specific details of your case, including imaging studies and biopsy results.

2. Lifelong Medication: After a total thyroidectomy, patients typically require lifelong thyroid hormone replacement therapy, usually in the form of levothyroxine. This is necessary because the thyroid gland produces hormones that regulate metabolism, and without it, patients can develop hypothyroidism, leading to symptoms such as fatigue, weight gain, and depression.
If only one lobe is removed, the remaining lobe may still produce enough thyroid hormone to maintain normal levels, but this is not guaranteed. Regular monitoring of thyroid hormone levels will be necessary to determine if medication is needed. If the remaining lobe becomes underactive or if any issues arise, medication may still be required.

3. Future Risks: Regarding your concern about the left lobe developing problems in the future, it is important to note that while many patients do well after lobectomy, there is still a risk of developing new nodules or even cancer in the remaining thyroid tissue. Regular follow-up with ultrasound and blood tests to monitor thyroid function and check for new nodules is essential.

4. Psychological and Physiological Considerations: It is understandable to have concerns about lifelong medication and its potential impact on your physiological functions. However, with proper management and regular follow-ups, many patients lead normal, healthy lives post-surgery. The key is to maintain open communication with your healthcare team, discuss any concerns you have, and ensure that you are monitored appropriately.

In summary, the decision between total thyroidectomy and lobectomy should be made based on the specific characteristics of your thyroid nodules and in consultation with your healthcare providers. Lifelong medication may be necessary depending on the surgical outcome, but with appropriate management, you can maintain a good quality of life. Always feel free to seek a second opinion if you feel uncertain about the recommendations provided.

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