Stage Migration in Lung Adenocarcinoma: A Patient's Journey - Oncology

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A family member was diagnosed with stage 2A lung adenocarcinoma and underwent thoracotomy, only to be informed afterward that it is actually stage 4. Does this mean the surgery was in vain?


Hello Dr.
Lai, the patient started coughing in October last year and continued seeking medical attention until being diagnosed with stage 2A lung adenocarcinoma in the middle of this year.
After several rounds of chemotherapy, a thoracotomy was scheduled last month.
However, post-surgery, the doctor informed us that metastasis was discovered during the procedure, and the diagnosis was upgraded to stage 4.
They were unable to proceed with the surgery and only performed a biopsy before closing up, which left family and friends quite shocked.

Could you please clarify, Dr.
Lai, why the preoperative PET scan and other tests did not reveal the metastasis? Was the thoracotomy a standard necessary procedure, or could it be that the surgeon's experience level led to an inaccurate assessment? (It took nearly a year from the onset of coughing to diagnosis.) Given that the patient is over seventy years old and has become physically weakened after this surgery, we would like to avoid further hospital transfers that could affect the patient's morale and will.
However, if there is a possibility of misjudgment by the doctor, we would consider seeking a second opinion at another hospital.
Thank you for taking the time to respond to the patient's concerns; we greatly appreciate it!

Xiao Mei, 20~29 year old female. Ask Date: 2016/11/21

Dr. Lai Yicheng reply Oncology


Dear Miss Xiao Mei,
1.
Positron Emission Tomography (PET) scans have certain limitations, such as the inability to accurately predict very small lymph nodes or small lesions in the brain or liver.
2.
Currently, the patient's condition is "inoperable," so I recommend:
A.
Radiation therapy combined with chemotherapy.

B.
Radiation therapy combined with targeted therapy (only if the EGFR gene mutation test is positive).
Thank you for your inquiry.
Sincerely,
Dr.
Lai Yi-Cheng
Department of Radiation Oncology
Changhua Hospital

Reply Date: 2016/11/21

More Info


Understanding stage migration in lung adenocarcinoma can be quite complex, especially when a patient experiences unexpected changes in their diagnosis during treatment. In your case, the transition from a diagnosis of stage IIa lung adenocarcinoma to stage IV during surgery is understandably shocking and raises many questions about the accuracy of preoperative assessments and the overall treatment approach.

Firstly, it is essential to understand that lung adenocarcinoma, like many cancers, can exhibit stage migration. This phenomenon occurs when the clinical staging of a cancer does not accurately reflect the pathological findings discovered during surgery. In your situation, the preoperative imaging, including PET scans and CT scans, may not have detected the metastatic disease due to several factors. These imaging modalities can sometimes miss small metastatic lesions, especially if they are not significantly enlarged or if they are located in areas that are difficult to visualize. Additionally, the sensitivity of imaging tests can vary based on the tumor's characteristics and the patient's unique anatomy.

The decision to proceed with surgery, despite the potential for metastasis, is often based on the best available information at the time. Surgeons typically rely on imaging studies, clinical evaluations, and the patient's overall health status to determine the appropriateness of surgical intervention. In many cases, surgery is considered a necessary step to obtain a definitive diagnosis through biopsy and to assess the extent of the disease. However, if metastasis is discovered during the procedure, it can lead to a change in treatment strategy, as was the case for your loved one.

Regarding the question of whether the surgery was a necessary step or if it reflects a lack of experience on the surgeon's part, it is crucial to recognize that surgical decisions are made based on the information available at that time. Even experienced surgeons can encounter unexpected findings during surgery. The goal of the operation is often to provide clarity on the disease's extent and to facilitate the best possible treatment plan moving forward.

In terms of next steps, it is vital to have open communication with the healthcare team. If there are concerns about the accuracy of the diagnosis or the treatment plan, seeking a second opinion can be a valuable option. This can provide additional insights and potentially alternative treatment strategies that may be more suitable for the patient's condition.

Moreover, considering the patient's age and overall health, the focus should also be on palliative care and quality of life. If the cancer has progressed to stage IV, treatment options may shift towards managing symptoms and maintaining comfort rather than aggressive curative measures.

In conclusion, while the experience of stage migration can be disheartening, it is a recognized aspect of cancer treatment. The best course of action is to engage in thorough discussions with the medical team, consider seeking a second opinion, and prioritize the patient's comfort and quality of life as they navigate this challenging journey.

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