Can You Rule Out HPV Infection After Negative Tests? - Urology

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In August, I regretted making a mistake by engaging in a one-night stand.
In November, I discovered a very small bump on my scrotum and suspected it might be genital warts.
I underwent a DNA test for HPV at a medical laboratory, carefully swabbing my genital area and the suspicious site.
I then visited a large hospital's urology department for a biopsy, where the diagnosis indicated that it did not resemble a wart lesion, and I was advised not to worry.
I also underwent STD testing, including blood and urine tests, which came back normal.
The attending physician mentioned that if there are no wart lesions after one month of sexual activity, then there is nothing to worry about.
However, I have read online and heard from some doctors that the incubation period can be three months or even up to a year, which causes me some concern.
Is there still a chance that I could have an undetected incubation period? Based on your experience, are the blood, urine, and biopsy tests at large hospitals accurate for diagnosing genital warts? What other precise tests could I consider? Thank you, doctor.

Mr. Chen, 30~39 year old female. Ask Date: 2016/11/25

Dr. Du Shixi reply Urology


Hello: The examinations at the medical center are still reliable, but the one-month timeframe is somewhat oversimplified.
It may be better to observe for a longer period.
Thank you for your inquiry.

Reply Date: 2016/11/25

More Info


When it comes to ruling out HPV (Human Papillomavirus) infection after receiving negative test results, it's important to understand the nuances of HPV testing and the nature of the virus itself.
Firstly, HPV is a common sexually transmitted infection, and while there are many types of HPV, only certain high-risk types are associated with cervical cancer and other anogenital cancers. The tests for HPV typically include HPV DNA tests, which detect the presence of the virus's genetic material, and Pap smears, which look for abnormal cell changes in the cervix.

In your case, you mentioned having a negative HPV DNA test and a subsequent examination that did not indicate the presence of warts (condyloma acuminata). This is a positive sign, as it suggests that you may not currently have an active HPV infection. However, it is crucial to note that HPV can sometimes remain dormant in the body for extended periods. The virus can be undetectable in tests even if it is present at low levels or if it has not yet caused any noticeable symptoms.

Regarding the concern about the incubation period of HPV, it is true that some strains of HPV can have a latency period where the virus is not detectable for months or even years after initial exposure. However, most people with HPV will clear the virus naturally within one to two years due to their immune system's response. The likelihood of developing symptoms or lesions, such as genital warts, typically occurs within a few weeks to months after infection, but this can vary.

As for the accuracy of the tests you underwent, large hospitals and specialized clinics generally provide reliable testing and diagnosis. The combination of a physical examination, biopsy, and laboratory tests (like blood and urine tests) can give a comprehensive view of your health status regarding HPV and other sexually transmitted infections (STIs). If your healthcare provider has assessed that the lesions you observed do not resemble condyloma and that your tests are normal, it is likely that you do not have an active HPV infection.

If you are still concerned about the possibility of an undetected HPV infection, you might consider discussing further testing options with your healthcare provider. They may recommend follow-up testing or monitoring over time, especially if you have any new symptoms or concerns.
In conclusion, while a negative HPV test is a reassuring indicator, it does not completely rule out the possibility of past infection or future risk. Maintaining regular check-ups, practicing safe sex, and considering HPV vaccination (if you haven't already) are proactive steps you can take to protect your health. If you have any lingering doubts or symptoms, don't hesitate to reach out to your healthcare provider for further evaluation and guidance.

Similar Q&A

Can a Negative HPV Test Three Months After Sex Rule Out Infection?

If HPV testing three months after sexual intercourse shows a negative result and a gynecologist examination reveals no lesions, can we rule out infection?


Dr. Du Shixi reply Urology
Please cherish our online medical resources. When asking the same question, please specify only one physician or nutritionist. Hello: It can generally be ruled out, but cauliflower can also manifest after several months, so safe practices are advised. Wishing you good health.

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Hello: There may not be any signs during the examination, but if there has been unsafe sexual behavior and the partner has HPV, there is a possibility of infection. Wishing you good health.

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I would like to ask the doctor, if the HPV test is negative (both high-risk and low-risk types), does it only indicate that there is no viral infection in the cervix? Or can it be inferred that other areas (such as the vulva, vagina, etc.) are also free of viral infection? Thank ...


Dr. Zhang Kunmin reply Obstetrics and Gynecology
Hello, the HPV test requires a sample to be taken from the area being examined, which means it only indicates whether that specific area is infected and cannot be used to infer the presence of infection in other areas. Wishing you peace and health, Dr. Zhang.

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Dr. Du Shixi reply Urology
Hello: 1) If there has been unprotected sexual intercourse, it is important to monitor for any unusual lumps or bumps. If the tests are accurate, it significantly reduces the risk. It is advisable to return for a follow-up to check for any signs of unprotected sexual activity. 2)...

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