Can Tetanus Vaccine Interact with Medications Like Cymbalta and Seroquel? - Family Medicine

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Will the tetanus vaccine and medications interact?


Hello, doctor.
I received a tetanus vaccine today, and I am currently taking Cymbalta and Seroquel.
I would like to know if I should avoid taking these medications for the next few days after the injection.

Mr. Hsu, 20~29 year old female. Ask Date: 2016/12/24

Dr. Liao Yaopan reply Family Medicine


Based on experience, there should not be any significant interactions; however, if there are concerns, it is advisable to discuss them with the prescribing physician.
Please note that online consultations do not equate to in-person visits and cannot provide diagnoses or treatment recommendations.
Changhua Hospital cares about you.

Reply Date: 2016/12/24

More Info


When considering the interaction of the Tetanus vaccine with medications such as Cymbalta (duloxetine) and Seroquel (quetiapine), it is important to understand the nature of the vaccine and the medications involved.

The Tetanus vaccine is a preventive measure designed to protect against tetanus, a serious bacterial infection that can cause muscle stiffness and spasms. The vaccine works by stimulating the immune system to produce antibodies against the tetanus toxin. It is generally well-tolerated, and side effects are usually mild, including soreness at the injection site, low-grade fever, or fatigue.

Cymbalta is an antidepressant that belongs to the class of serotonin-norepinephrine reuptake inhibitors (SNRIs). It is commonly prescribed for major depressive disorder, generalized anxiety disorder, fibromyalgia, and chronic pain conditions. Seroquel, on the other hand, is an atypical antipsychotic used to treat schizophrenia, bipolar disorder, and as an adjunct treatment for major depressive disorder.
In terms of drug interactions, there is no direct contraindication or significant interaction between the Tetanus vaccine and either Cymbalta or Seroquel. The administration of the Tetanus vaccine should not interfere with the efficacy of these medications. However, it is always prudent to monitor for any unusual side effects or reactions after receiving a vaccine, especially if you are on multiple medications.

It is also worth noting that while the Tetanus vaccine does not interact with Cymbalta or Seroquel, the medications themselves can have their own side effects that may be exacerbated by the stress of vaccination or by any mild fever or discomfort that may occur post-vaccination. For example, both Cymbalta and Seroquel can cause sedation or dizziness, and if you experience these side effects after vaccination, it may be wise to avoid activities that require full alertness.

In conclusion, you can continue taking Cymbalta and Seroquel after receiving the Tetanus vaccine without concern for significant interactions. However, if you have any specific health conditions or concerns, or if you experience any unusual symptoms after vaccination, it is always best to consult with your healthcare provider for personalized advice. They can provide guidance based on your overall health status and medication regimen.
In summary, while the Tetanus vaccine is generally safe to administer alongside Cymbalta and Seroquel, always keep an open line of communication with your healthcare provider regarding any concerns about your medications and vaccinations. Your health and safety should always be the priority.

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