Syphilis Treatment: Effective vs. Complete Cure Explained - Urology

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About syphilis?


Hello Doctor, I would like to ask if the definitions of "effective treatment" and "complete cure" for syphilis are the same.
I previously used oral medication (during the summer of 2014), but it was not effective, so I received an injection (in 2015).
If the treatment was effective but did not completely cure the infection, is it still possible for related symptoms to appear on the body, such as ulcers on the penis? (Recently, I noticed a lesion on my penis that resembles an ulcer; it has flaky skin, and if I accidentally apply too much pressure, it breaks and bleeds, creating a small wound...) Additionally, I have recently developed a red, lump-like lesion near my neck and jaw that looks similar to pityriasis rosea.
Could this also be a symptom related to this disease? (It itches and hurts when pressed, and I feel the urge to scratch it.) Is it possible that this indicates a recurrence? I would appreciate your clarification, thank you.

Niming, 20~29 year old female. Ask Date: 2017/02/01

Dr. Du Shixi reply Urology


Hello: Syphilis requires regular follow-up.
After initial treatment, follow-up should occur at 3 months, and then every 6 months for a year.
If the titers increase, it is important to be vigilant.
Your issue is difficult to determine as a relapse, so blood tests should be combined for evaluation.
Additionally, other sexually transmitted infections should also be considered.
It is recommended that you consult a physician promptly.
Thank you for your inquiry.

Reply Date: 2017/02/01

More Info


When discussing syphilis treatment, it's important to differentiate between "effective treatment" and "complete cure." Effective treatment typically refers to the administration of appropriate antibiotics that can reduce the bacterial load and alleviate symptoms associated with syphilis. However, a complete cure means that the infection has been fully eradicated from the body, and no further symptoms or complications are present.

In your case, it sounds like you initially received oral treatment for syphilis in 2014, which was followed by an injection in 2015 due to inadequate response. If the treatment was effective, it should have significantly reduced or eliminated the symptoms associated with syphilis. However, if you are experiencing new symptoms, such as a sore on the penis that resembles an ulcer, it is essential to consider the possibility of reinfection or a relapse of the disease.

Syphilis can present with various symptoms, and the appearance of ulcers or sores on the genital area can be indicative of several conditions, including a recurrence of syphilis or other sexually transmitted infections (STIs). The ulcer you described, especially if it has a crusty appearance and bleeds when irritated, warrants immediate medical attention. It is crucial to have a healthcare provider evaluate this sore to determine its cause and appropriate treatment.

Additionally, the red, raised lesion you mentioned near your neck and jaw could also be related to syphilis or another dermatological condition. While syphilis can cause skin rashes, the specific characteristics of your lesion (itching, pain, etc.) may suggest a different issue, such as an allergic reaction or another skin infection.
It is also important to note that syphilis can have latent stages where the bacteria remain in the body without causing symptoms. If left untreated, syphilis can progress to more severe stages, leading to complications affecting various organs. Therefore, if you suspect a recurrence or new symptoms, it is vital to seek medical evaluation promptly.

In summary, while effective treatment can alleviate symptoms, it does not always guarantee a complete cure. If you are experiencing new symptoms, it is crucial to consult a healthcare provider for a thorough examination and appropriate testing. They may recommend blood tests to check for syphilis and other STIs, as well as a physical examination of the lesions you described. Early diagnosis and treatment are key to preventing complications and ensuring your overall health.

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