Recurrent Genital Herpes: Symptoms, Treatments, and New Vaccines - Urology

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Genital herpes issues?


Hello Dr.
Du,
Last March, I had unprotected sexual intercourse, and two weeks later, I developed symptoms.
Initially, I experienced itching, followed by redness, swelling, ulcers, and crusting, which lasted about a week before I recovered.
I went to the urology department for an examination, and the doctor suspected it might be herpes.
Subsequently, I had a blood test, which showed no infection.
In October of last year, I had a second outbreak.
At that time, I might have had a slight cold, and I forgot whether the cold medication I took contained antibiotics.
The recurrence presented as itching, peeling, mild ulcers, and I recovered without crusting.
In February of this year, I had a third recurrence.
This time, the symptoms were somewhat different.
Initially, there were no abnormalities in the genital area, but after I finished taking the cold medication (which I confirmed contained antibiotics), I felt dizzy and slightly weak in my limbs, likely due to the medication.
At that point, the itching in the genital area began, so I took antiviral medication and applied ointment.
This significantly shortened the recovery time from itching to redness, mild peeling, and recovery (without ulcers or crusting).
I would like to ask Dr.
Du the following questions:
1.
Can antibiotics trigger the activation of the herpes virus?
2.
With multiple recurrences, does the condition tend to lessen due to the increasing number of outbreaks, or is it because I took antiviral medication and ointment immediately upon noticing symptoms?
3.
For each recurrence, can I purchase antiviral oral medication and ointment over the counter? I feel a bit embarrassed going to the urology department for genital herpes infections (unless it has been over a week without recovery, can I self-medicate?).
4.
Based on my current recurrence timeline, is it too frequent? The time from the initial outbreak to the first recurrence was 7 months, and the second recurrence was 4 months.
5.
Additionally, I found news about the American biotechnology company Rational Vaccines, which is developing the phase 1 TheravaxHSV-2 vaccine.
The results of the human trials seem promising.
Does this mean it could be a curative vaccine, or is it just expected to achieve better efficacy than the currently used medications, Valacyclovir and Acyclovir?
I apologize for the many questions.
Thank you, Dr.
Du.

Hemo, 20~29 year old female. Ask Date: 2017/02/08

Dr. Du Shixi reply Urology


Hello: Regarding your skin changes being considered as herpes, please note the following: 1) It may not be herpes.
2) Frequent recurrences indicate that your immune system may be weakened and the virus is active.
3) You should seek medical attention and get checked for any other issues (please visit a urology department).
4) Therefore, it is safer for you to see a doctor.
5) Vaccines are for prevention, while acyclovir is for treatment; these are different concepts.
Prevention also targets different strains, and currently, it seems that there is no comprehensive solution for herpes.
Maintaining a normal immune system, avoiding late nights, and reducing alcohol consumption are common recommendations I see in my practice.
As long as you maintain a normal lifestyle, the chances of recurrence will decrease.
Additionally, please be aware that you are particularly contagious when symptoms are present, so practice safe sex.

Reply Date: 2017/02/08

More Info


Understanding recurrent genital herpes can be quite complex, especially when considering the symptoms, treatments, and the potential for new vaccines. Genital herpes is primarily caused by the herpes simplex virus type 2 (HSV-2), although it can also be caused by type 1 (HSV-1) through oral-genital contact. The symptoms typically include itching, burning, and painful sores in the genital area, which can recur periodically.

1. Antibiotics and Herpes Activation: Antibiotics are designed to treat bacterial infections and do not have any direct effect on viral infections like herpes. However, they can alter the body's microbiome and immune response, potentially leading to changes in how the body handles viral infections. While antibiotics themselves do not activate the herpes virus, any stress on the body, including infections or medications, can trigger a herpes outbreak in individuals who are already infected.

2. Recurrence and Severity: The frequency of outbreaks can vary significantly among individuals. Some people may experience more frequent recurrences initially, which may decrease over time as the immune system learns to manage the virus. The fact that you are taking antiviral medications like acyclovir or valacyclovir at the onset of symptoms is beneficial. These medications can help reduce the duration and severity of outbreaks, leading to quicker recovery times. It’s also possible that with each subsequent outbreak, the symptoms may become milder, but this is not guaranteed for everyone.

3. Self-Medication with Antivirals: It is generally acceptable to have a supply of antiviral medications on hand for recurrent outbreaks, especially if you have a history of frequent recurrences. However, it is crucial to consult with a healthcare provider to ensure that you are using the medications correctly and to discuss any potential side effects or interactions with other medications you may be taking. If you find that your symptoms are manageable and you can recognize the onset of an outbreak, self-treatment may be appropriate, but always consider professional guidance.

4. Frequency of Recurrences: The timeline you provided indicates that your outbreaks are becoming more frequent, which can be concerning. The initial outbreak can sometimes be followed by several recurrences in the first year, but as time goes on, many individuals experience fewer outbreaks. If you find that your outbreaks are too frequent or are causing significant distress, it may be worth discussing with a healthcare provider whether a suppressive therapy regimen (daily antiviral medication) might be appropriate for you.

5. New Vaccines and Treatments: The research into vaccines like the one from Rational Vaccines is promising, but it is essential to understand that while these vaccines may show efficacy in clinical trials, they are not yet widely available or proven to be a cure for herpes. Current antiviral medications like valacyclovir and acyclovir are effective in managing outbreaks and reducing transmission risk, but they do not eliminate the virus from the body. New vaccines may offer better prevention or treatment options, but until they are fully developed and approved, the standard antiviral treatments remain the primary method of managing genital herpes.

In conclusion, managing recurrent genital herpes involves understanding your body's responses, recognizing triggers, and utilizing antiviral medications effectively. It is always advisable to maintain open communication with your healthcare provider to tailor a management plan that suits your needs. If you have further questions or concerns, especially regarding new treatments or vaccines, do not hesitate to reach out for professional advice.

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