Menstrual Induction: Concerns for PCOS Patients - Obstetrics and Gynecology

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Menstrual induction issues?


Hello Doctor, I am a patient with severe polycystic ovary syndrome (PCOS).
Without medication to induce menstruation, my period does not come.
I have been returning for check-ups every 2 to 3 months to induce menstruation because I want to conceive naturally, so I have not been using contraception.
This time, I took the medication to induce menstruation for 3 days starting on February 28.
According to my previous experience, my period usually arrives on the 4th day after finishing the medication.
However, it has been a week since I finished the medication, and my period has not come.

I have two questions:
1.
On February 28, after taking the first day of the medication, I had intercourse.
Is there a possibility of conception?
2.
Although my period has not arrived, I am experiencing breast tenderness (similar to premenstrual symptoms).
On the 7th day of my missed period, I had a follow-up appointment where a pregnancy test showed only one line, and an ultrasound indicated that my endometrium is thickened with no signs of pregnancy.
The doctor mentioned that the response to the medication can vary for each individual and may take 7 to 10 days.
I was advised to wait and see.
If I want to take a home pregnancy test, when would be the most accurate time to do so?

Niming, 30~39 year old female. Ask Date: 2017/03/11

Dr. Huang Jianzhong reply Obstetrics and Gynecology


I am a patient with severe polycystic ovary syndrome (PCOS) and my menstrual period does not occur without medication.
I have regular check-ups every 2 to 3 months for menstrual induction because I want to conceive naturally, so I have not been using contraception.
This time, on February 28, I took menstrual induction medication for 3 days.
According to past experience, my period usually starts on the 4th day after finishing the medication.
However, a week after completing the medication, my period still has not arrived.

1.
I had intercourse on the first day of taking the menstrual induction medication (February 28).
Is there a possibility of pregnancy?
Answer: The possibility of pregnancy is low.
2.
My period has not arrived, but I experience breast tenderness (similar to pre-menstrual symptoms).
On the 7th day of my missed period, I had a follow-up appointment where a pregnancy test showed only one line, and an ultrasound indicated a thickened endometrium with no signs of pregnancy.
The doctor mentioned that the response to the menstrual induction medication varies among individuals and may take 7 to 10 days.
I was advised to wait and see.
If I want to take a home pregnancy test, when would be the most accurate day to test?
Answer: The most accurate day to test would be 14 days after the missed period.

Reply Date: 2017/03/11

More Info


Understanding menstrual induction, especially for patients with Polycystic Ovary Syndrome (PCOS), can be quite complex. PCOS is a hormonal disorder that affects women of reproductive age and is characterized by irregular menstrual cycles, excess androgen levels, and polycystic ovaries. For those with severe PCOS, menstrual induction may be necessary to regulate cycles and improve fertility chances.

1. Possibility of Pregnancy After Induction: If you took menstrual induction medication on February 28 and had unprotected intercourse on the same day, there is a possibility of pregnancy. However, the effectiveness of the induction medication can vary. Typically, these medications work to stimulate the lining of the uterus and promote menstruation, but they do not guarantee that ovulation will occur immediately. If ovulation does not happen, the chances of conception are significantly reduced.
2. Delayed Menstruation and Symptoms: It’s not uncommon for women with PCOS to experience delayed menstruation even after taking induction medication. The hormonal fluctuations associated with PCOS can lead to a delayed response to medications. The breast tenderness you are experiencing is a common premenstrual symptom, but it can also occur due to hormonal changes unrelated to menstruation.
3. Timing for Home Pregnancy Tests: If your period is delayed by a week and you have not seen any signs of menstruation, it is advisable to wait a few more days before taking a home pregnancy test. Most home pregnancy tests are designed to detect the hormone hCG (human chorionic gonadotropin), which is produced after a fertilized egg implants in the uterus. Testing too early can lead to false negatives. Generally, testing about a week after your expected period is recommended for the most accurate results.

4. Consulting with Your Doctor: Since you have already scheduled a follow-up appointment, it’s essential to discuss your symptoms and concerns with your healthcare provider. They can provide personalized advice based on your medical history and current condition. If your menstrual cycle remains irregular or if you continue to experience symptoms without a clear diagnosis, further evaluation may be necessary.

5. Long-Term Management of PCOS: Managing PCOS often requires a multifaceted approach, including lifestyle changes, medication, and sometimes surgical interventions. Weight management, a balanced diet, and regular exercise can significantly improve symptoms and fertility outcomes. Medications such as Metformin may be prescribed to help regulate insulin levels, which can, in turn, help manage menstrual cycles and improve ovulation.

6. Potential Side Effects of Induction Medications: It’s important to be aware that menstrual induction medications can have side effects, including mood swings, bloating, and changes in breast tenderness. If you experience severe side effects or have concerns about the medications you are taking, consult your healthcare provider for alternatives or adjustments to your treatment plan.

In conclusion, while the journey to managing PCOS and achieving pregnancy can be challenging, understanding your body and maintaining open communication with your healthcare provider can help you navigate this process more effectively. Regular monitoring and tailored treatment plans can significantly enhance your chances of conception and overall reproductive health.

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