Drusen and RPE Changes in Macular Degeneration - Ophthalmology

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Macular scarring


Hello Doctor: I recently had an OCT examination at the ophthalmology department, and the doctor mentioned that my retinal pigment epithelium (RPE) has a slight depression, which is believed to be caused by scarring.
Structurally, it is not drusen and will not progress to wet age-related macular degeneration (AMD).
I have a few questions: 1.
Does the presence of scarring in the macula indicate dry age-related macular degeneration? 2.
Does scarring mean that the condition is stable and will not worsen? However, why did the doctor say that the scarring indicates a stable recovery and that I only need to have regular follow-ups? Thank you for your response, Doctor.

JJ, 30~39 year old female. Ask Date: 2017/03/13

Dr. Cai Wenyuan reply Ophthalmology


Hello, your question may need to be directed to the attending physician.
Thank you.
Wishing you safety and health.
Sincerely, Dr.
Cai Wenyuan, Director of the Ophthalmology Department, Taoyuan Hospital, Ministry of Health and Welfare.

Reply Date: 2017/03/13

More Info


Hello! Thank you for your questions regarding Drusen and RPE (Retinal Pigment Epithelium) changes in the context of macular degeneration. It’s great that you’re seeking to understand your eye health better. Let’s break down your concerns.

1. Is the presence of Drusen indicative of dry macular degeneration?
Yes, the presence of Drusen is typically associated with dry age-related macular degeneration (AMD). Drusen are yellowish deposits that form under the retina, specifically beneath the RPE. They are considered one of the early signs of dry AMD. However, not all individuals with Drusen will progress to advanced stages of AMD, and the presence of Drusen alone does not confirm that you have dry AMD. It is essential to monitor the size, number, and characteristics of Drusen over time, as these factors can influence the risk of progression to more severe forms of macular degeneration.

2. Does the presence of scarring (or RPE changes) mean the condition is stable and will not worsen?
The presence of scarring or changes in the RPE can indicate previous damage or degeneration, but it does not necessarily mean that the condition is stable or that it will not worsen in the future. RPE changes can be a sign of the body’s response to injury or degeneration, and while some changes may stabilize, others can progress. The fact that your doctor mentioned that the RPE changes are not indicative of wet AMD is reassuring, as wet AMD is often associated with more severe vision loss and requires more immediate intervention.

3. Why did the doctor say that the scarring is stable and recovering, yet you need regular follow-ups?
The statement about the scarring being stable and in a recovery phase suggests that your eye is healing from a previous insult, which is a positive sign. However, the need for regular follow-ups is crucial in monitoring any potential changes in your condition. Macular degeneration can be unpredictable, and regular monitoring allows for early detection of any progression, whether it be towards dry or wet AMD. Your doctor likely wants to ensure that any changes in your vision or the appearance of new Drusen or RPE changes are caught early, allowing for timely intervention if necessary.

In summary, while the presence of Drusen and RPE changes can indicate dry AMD, it does not guarantee stability. Regular follow-ups are essential to monitor your condition and ensure that any changes are addressed promptly. If you have further concerns or notice any changes in your vision, do not hesitate to reach out to your eye care provider. They can provide personalized advice and management strategies based on your specific situation.
It's also worth noting that maintaining a healthy lifestyle, including a balanced diet rich in antioxidants, regular exercise, and avoiding smoking, can help support eye health and potentially slow the progression of AMD. Thank you for your questions, and I hope this information helps clarify your concerns!

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