Do I Need to Continue Progesterone Supplementation After a Positive Pregnancy Test?

Progesterone supplementation

Previously, my doctor noted that I had insufficient progesterone based on my basal body temperature and prescribed natural progesterone (Utrogestan) for supplementation, to be taken once in the morning and once in the evening after ovulation.
Later, when my husband and I went abroad for work, I bought a box of Utrogestan at the pharmacy before leaving as a backup.
I continued to monitor my temperature and discharge, starting the supplementation after each ovulation.
My last menstrual period was on February 14, and today (March 16), I tested positive for pregnancy.
In the absence of any bleeding, should I continue to supplement with progesterone? What is the recommended dosage? Until when should I take it? Is there a risk of over-supplementation? Thank you!

Sophie, 30~39 year old female. Ask Date: 2017/03/16

Dr. Huang Jianzhong reply Obstetrics and Gynecology

Previously, the doctor noted that I had insufficient progesterone based on my basal body temperature and prescribed natural progesterone (Utrogestan) for supplementation, to be taken once in the morning and once in the evening after ovulation.
Later, my husband and I went abroad for work, and before leaving, I bought a box of Utrogestan as a backup.
I continued to monitor my temperature and discharge, starting supplementation after each ovulation.
My last menstrual period was on February 14, and this morning (March 16), I tested positive for pregnancy.
In the absence of bleeding, should I continue to supplement with progesterone? What is the recommended dosage? Until when should I take it? Is there a risk of overdosing?
Answer: Continuing progesterone supplementation after pregnancy has varying opinions, and this question is difficult to answer.

Reply Date: 2017/03/16

More Info

When it comes to continuing progesterone supplementation after a positive pregnancy test, the answer is not straightforward and can vary based on individual circumstances. In your case, since you have a history of low progesterone levels and have been prescribed natural progesterone (Utrogestan) to support your pregnancy, it is generally advisable to continue supplementation, especially in the early stages of pregnancy.

Progesterone plays a crucial role in maintaining a healthy pregnancy. It helps to prepare the uterine lining for implantation of the embryo and supports the early stages of pregnancy by preventing uterine contractions that could lead to miscarriage. Given your previous diagnosis of low progesterone and the fact that you are now pregnant, continuing to take Utrogestan can help stabilize your pregnancy during this critical period.

In terms of dosage, you mentioned that you were taking one capsule of Utrogestan twice daily. This regimen is commonly prescribed, but it is essential to follow your healthcare provider's recommendations. If you have not experienced any bleeding or other complications, many doctors suggest continuing progesterone supplementation until around the end of the first trimester (approximately 12 weeks of gestation). However, some may recommend continuing for a longer duration, depending on individual risk factors and medical history.

Regarding concerns about overdosing on progesterone, it is important to adhere to the prescribed dosage. While progesterone is generally considered safe during pregnancy, excessive amounts can lead to side effects. Common side effects of high progesterone levels may include fatigue, mood swings, and breast tenderness. However, these symptoms are often mild and manageable. If you have any concerns about the dosage or experience any unusual symptoms, it is crucial to consult your healthcare provider.

Additionally, it is worth noting that while progesterone supplementation can be beneficial, it is not a guarantee against miscarriage. Factors such as chromosomal abnormalities, uterine abnormalities, and other health issues can also contribute to pregnancy loss. Therefore, maintaining regular prenatal care and following your doctor's advice is vital for monitoring the health of both you and your developing baby.

In summary, based on your history of low progesterone and the fact that you are now pregnant, it is generally advisable to continue taking Utrogestan until your healthcare provider advises otherwise. Always communicate openly with your doctor about any concerns or symptoms you may have, and ensure that you have regular check-ups to monitor your pregnancy's progress. Remember, every pregnancy is unique, and your healthcare provider is the best resource for personalized advice tailored to your specific situation.

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