Medication Side Effects for Stomach Ulcers - Gastroenterology and Hepatology

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Medications for Peptic Ulcer Disease


I have a stomach ulcer and took Aiwai Reverse, Gasker 40 mg, and Changfulu enteric-coated tablets.
After taking them, I felt weakness in my limbs, and my calves were extremely sore.
I did some research online and found that Aiwai Reverse contains magnesium.
Could this be causing my discomfort? Please help me with this question.
Thank you.

Shih Hsin-Yun, 40~49 year old female. Ask Date: 2017/03/29

Dr. Cai Anshun reply Gastroenterology and Hepatology


Hello: You may first remove the enteric-coated tablets of Changfu.
Its ingredients (Pancreatin 212.5mg + Metoclopramide HCl 5mg) include the motility-promoting component Metoclopramide, which may be related to your symptoms.
Additionally, if you experience any discomfort while taking the medication, you can return to the gastroenterology department for a reevaluation.
Changhua Hospital cares about your health.
Dr.
Tsai An-shun.

Reply Date: 2017/03/29

More Info


When dealing with stomach ulcers, understanding the potential side effects of medications is crucial for effective management and overall health. In your case, you mentioned taking medications such as Aiwai Reverse (艾胃逆服), Gaske Er (加斯克兒錠), and Changfu coated tablets (暢腹立膜衣錠). You are experiencing symptoms like weakness in your limbs and significant calf pain, which raises concerns about the side effects of these medications.

Firstly, let's break down the medications you are taking. Aiwai Reverse contains magnesium, which is often used to neutralize stomach acid and can help alleviate symptoms associated with ulcers. However, high doses of magnesium can lead to side effects such as diarrhea, abdominal cramping, and in some cases, muscle weakness or fatigue, especially if kidney function is impaired. This could explain the weakness you are feeling in your limbs.

Gaske Er, which is likely a proton pump inhibitor (PPI), is commonly prescribed for stomach ulcers as it reduces stomach acid production. While PPIs are generally safe and effective, long-term use can lead to side effects such as nutrient malabsorption (particularly magnesium, calcium, and vitamin B12), which could contribute to feelings of weakness or fatigue. Additionally, PPIs can sometimes cause gastrointestinal symptoms like bloating or discomfort, which may exacerbate your overall condition.

Changfu coated tablets contain ingredients that promote gastrointestinal motility and may help with digestion. However, medications that stimulate the gut can also lead to side effects such as cramping, diarrhea, or discomfort, which might contribute to your symptoms.

Given your symptoms of limb weakness and calf pain, it is essential to consider a few factors:
1. Medication Interaction: The combination of these medications may lead to compounded side effects. For example, if Aiwai Reverse is causing gastrointestinal upset, it could lead to decreased nutrient absorption, contributing to your feelings of weakness.

2. Nutritional Deficiencies: As mentioned earlier, long-term use of PPIs can lead to deficiencies in essential nutrients. It would be wise to discuss with your healthcare provider whether you should have your magnesium levels checked, as low magnesium can lead to muscle cramps and weakness.

3. Kidney Function: If you have any underlying kidney issues, magnesium can accumulate in the body and lead to toxicity, which can manifest as muscle weakness and other symptoms. It’s crucial to ensure your kidney function is normal.

4. Consultation with a Specialist: Given the complexity of your symptoms and the medications you are taking, it would be prudent to consult a gastroenterologist. They can evaluate your condition more thoroughly, consider adjusting your medications, or suggest alternatives that may be less likely to cause side effects.

5. Lifestyle and Dietary Adjustments: Alongside medication, lifestyle changes such as a balanced diet rich in nutrients, staying hydrated, and managing stress can significantly impact your recovery from ulcers and overall well-being.

In conclusion, while the medications you are taking are standard treatments for stomach ulcers, they can have side effects that may contribute to your current symptoms. It is essential to communicate openly with your healthcare provider about your experiences, as they can help tailor your treatment plan to minimize side effects and improve your quality of life. Always prioritize regular check-ups and monitoring, especially when on long-term medication regimens.

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