Does Priligy Affect OCD Symptoms? Duration and Side Effects Explained - Urology

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Premature ejaculation medications


Hello, the medication Priligy (dapoxetine) for premature ejaculation seems to affect serotonin levels.
If a patient has obsessive-compulsive disorder (OCD) and is not taking other medications, will taking Priligy exacerbate OCD symptoms or cause other side effects? How long should one take Priligy before considering discontinuation? Thank you.

Niming, 40~49 year old female. Ask Date: 2017/04/03

Dr. Xu Wencang reply Urology


Please have a physician evaluate the situation.
Bupropion is an SSRI used to treat depression, similar to other medications in its class.
It is advisable to consult a physician for assessment.

Reply Date: 2017/04/03

More Info


Priligy, known generically as dapoxetine, is a medication primarily used to treat premature ejaculation. It functions as a selective serotonin reuptake inhibitor (SSRI), which means it increases serotonin levels in the brain. While SSRIs are often prescribed for conditions such as depression and anxiety disorders, including obsessive-compulsive disorder (OCD), their effects can vary significantly among individuals, particularly when it comes to OCD symptoms.

In patients with OCD, the relationship between serotonin and symptoms is complex. SSRIs, including Priligy, can sometimes help alleviate OCD symptoms by enhancing serotonin transmission. However, the use of Priligy specifically for OCD is not well-established, and its primary indication is for premature ejaculation. Therefore, while it may have some impact on serotonin levels, it is not typically used as a treatment for OCD.

Regarding your concern about whether Priligy could exacerbate OCD symptoms, it is essential to consider individual responses to medications. Some individuals may experience an improvement in their OCD symptoms due to the increased serotonin levels, while others might find that their symptoms worsen. This variability can depend on several factors, including the individual's unique neurochemistry, the presence of comorbid conditions, and the dosage of the medication.

As for side effects, common adverse effects of Priligy include nausea, dizziness, headache, and fatigue. These side effects can sometimes overlap with symptoms experienced by individuals with OCD or anxiety disorders, potentially complicating the clinical picture. Additionally, since Priligy is a relatively short-acting SSRI, it is typically taken on an as-needed basis rather than daily, which may influence its overall impact on OCD symptoms.

Regarding the duration of treatment, the decision to continue or discontinue Priligy should be made in consultation with a healthcare provider. Generally, the medication can be taken as needed before sexual activity, and there is no established long-term treatment regimen for OCD with Priligy. If a patient finds that their OCD symptoms are worsening or if they experience significant side effects, it is crucial to discuss these concerns with a healthcare professional. They may recommend adjusting the dosage, switching to a different medication, or incorporating additional therapeutic modalities, such as cognitive-behavioral therapy (CBT), which is particularly effective for OCD.

In summary, while Priligy may influence serotonin levels, its effects on OCD symptoms are not well-documented, and individual responses can vary widely. It is essential to monitor any changes in OCD symptoms closely and maintain open communication with a healthcare provider to ensure that the treatment plan is tailored to the individual's needs. If you have further questions or concerns about your treatment, please consult your healthcare provider for personalized advice.

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