Liver Issues: Questions About Fatty Liver and Abnormal Enzymes - Gastroenterology and Hepatology

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Liver issues?


Dear Dr.
Tsai,
I am the patient who consulted you regarding my condition.
My ultrasound report is the same as last time, but my GOT is 32 and GPT is 57, which is abnormal.
I have a few questions I would like to ask:
1.
I have been taking iron supplements; last year I took them for three months, my hemoglobin levels normalized, but I became anemic again after stopping the medication.
This year, I continued taking them for two months and have been regularly monitored.
2.
For the past three months, I have experienced swelling and soreness in my calves, and I have been visiting an orthopedic doctor, receiving anti-inflammatory injections multiple times.
3.
I have gained 6 kilograms from last year to this year and have been diagnosed with fatty liver.
Dr.
Tsai, are my abnormal liver enzyme levels related to the issues mentioned above? My spleen measures 5.7 x 4.1 cm.
Is a score of 6 on the ultrasound report considered severe? What can be done to normalize my liver enzyme levels, and how can we identify the underlying cause?
Thank you very much!

Piqiu, 40~49 year old female. Ask Date: 2017/04/10

Dr. Cai Anshun reply Gastroenterology and Hepatology


Hello: 1.
For fatty liver, it is important to exercise and control caloric intake.
If fatty liver improves, liver enzyme levels should normalize (assuming there is no chronic hepatitis B or C).
2.
Anemia can also lead to muscle soreness.
3.
In cases of fibrosis, regular monitoring is recommended, and there is no need to be overly concerned.
Changhua Hospital cares about your health.
Dr.
Tsai An-Shun.

Reply Date: 2017/04/10

More Info


Fatty liver disease, also known as hepatic steatosis, is a condition characterized by an excessive accumulation of fat in the liver. It can lead to inflammation and damage, potentially progressing to more severe liver diseases such as non-alcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. Your concerns regarding abnormal liver enzyme levels (GOT and GPT) and the implications of fatty liver are valid and warrant a comprehensive understanding.

1. Understanding Abnormal Liver Enzymes: Elevated liver enzymes, such as GOT (AST) and GPT (ALT), can indicate liver inflammation or damage. In your case, the levels of GOT (32) and GPT (57) are above the normal range, which typically should be below 40. These elevations can indeed be associated with fatty liver disease. However, they do not necessarily indicate severe liver damage or inflammation. The liver can often recover from mild to moderate elevations in these enzymes, especially with lifestyle modifications.

2. Reversibility of Liver Damage: One of the most encouraging aspects of fatty liver disease is that it is often reversible. Weight loss, particularly a reduction of 7-10% of body weight, can significantly improve liver health and reduce fat accumulation in the liver. This can lead to normalization of liver enzymes and improvement in liver histology. Dietary changes, such as adopting a balanced diet low in saturated fats and sugars, and increasing physical activity, can also contribute to liver health. Regular follow-ups with your healthcare provider are essential to monitor liver function and make necessary adjustments to your treatment plan.

3. Dietary Adjustments: To manage fatty liver, it is crucial to focus on a healthy diet. Incorporating whole grains, such as oats, is a positive step. Additionally, consider the following dietary recommendations:
- Increase Fiber Intake: Include plenty of fruits, vegetables, and whole grains to improve digestion and reduce fat absorption.

- Healthy Fats: Opt for unsaturated fats found in olive oil, avocados, and nuts, while avoiding trans fats and excessive saturated fats.

- Limit Sugars and Refined Carbohydrates: Reduce intake of sugary beverages, sweets, and white bread, which can contribute to fat accumulation.

- Stay Hydrated: Drink plenty of water and limit alcohol consumption, as alcohol can exacerbate liver damage.

4. Understanding the Severity of Fatty Liver: The severity of fatty liver can vary significantly among individuals. A score of 6 on a liver fibrosis score may indicate mild fibrosis, but it is essential to interpret this in the context of your overall health and other diagnostic findings. Regular monitoring through imaging studies and blood tests can help assess the progression of liver disease.

5. Addressing Other Health Concerns: Your mention of anemia and calf pain may also be relevant. Anemia can be caused by various factors, including nutritional deficiencies or chronic disease. It is essential to work with your healthcare provider to investigate the underlying causes of your anemia and calf pain, as these may indirectly affect your liver health.

In summary, while your liver enzyme levels are elevated, there are effective strategies to improve your liver health. Focus on weight management through diet and exercise, and maintain regular follow-ups with your healthcare provider to monitor your liver function and overall health. By addressing these issues holistically, you can work towards normalizing your liver enzymes and improving your overall well-being.

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