Why Do Hives Flare Up Every Evening? Nighttime Allergies - Dermatology

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It occurs at night?


Hello, doctor.
Last week, I visited a clinic due to a cold, and the doctor prescribed medication for three days.
By the third day, my cold was mostly resolved, but I started experiencing symptoms of urticaria (hives).
On that day, I had eaten eggs, and I had a positive reaction to eggs in an allergy test two years ago.
However, I had not experienced any allergic reactions to eggs for over a decade prior to this cold.
After this cold, the urticaria began to manifest.
I also visited the emergency room two days ago, and I have been taking the prescribed medication.
During the day, I feel fine, but as soon as it gets to evening or night, the symptoms start to flare up.
This issue has been bothering me for the past two to three days.
I would like to ask the doctor, what could be the reason for the symptoms consistently occurring at night?

Piao Zhenghao, 20~29 year old female. Ask Date: 2017/04/19

Dr. Li Yufen reply Dermatology


Hello: Regarding the introduction to urticaria, you can refer to Dr.
Cheng Shih-Tzung's article at http://www.kmuh.org.tw/www/kmcj/data/8705/3595.htm.
The onset occurring at night may be due to re-exposure to allergens or the expiration of medication effectiveness, among other reasons.
It is recommended that if your skin abnormalities persist or worsen, you should consult a nearby dermatologist for diagnosis and treatment.
http://www.derma.org.tw/user_finddoctor.php Thank you!

Reply Date: 2017/04/19

More Info


Hives, or urticaria, can indeed be perplexing, especially when they seem to flare up at specific times, such as in the evening. Your experience of developing hives after a recent illness, particularly after consuming an allergenic food like eggs, raises several important considerations regarding your immune response and potential triggers.

Firstly, it's essential to understand that hives are a result of the body's immune system reacting to certain triggers, which can include allergens, medications, stress, or even temperature changes. In your case, the fact that you have a known allergy to eggs suggests that your immune system may be more sensitized to this allergen, especially after a recent illness. When the body is fighting off an infection, such as a cold, it can become more reactive to allergens due to changes in immune function and inflammation.

The timing of your hives—flaring up in the evening—could be attributed to several factors:
1. Circadian Rhythms: The body's immune system operates on a circadian rhythm, meaning that its activity can vary throughout the day. Some studies suggest that certain immune responses may be heightened in the evening, potentially making you more susceptible to allergic reactions at that time.

2. Environmental Factors: Evening hours may bring about changes in your environment that could trigger hives. For instance, if you are exposed to dust mites, pet dander, or other allergens in your home, these could contribute to your symptoms. Additionally, temperature changes, such as moving from a warm environment to a cooler one, can also provoke hives.

3. Stress and Fatigue: After a long day, your body may be more fatigued and stressed, which can exacerbate allergic reactions. Stress can lead to the release of histamines, the chemicals responsible for hives, thus triggering an outbreak.

4. Food Intake: If you are consuming meals in the evening that contain allergens or other irritants, this could also explain the timing of your hives. Even if you have eaten eggs without issue in the past, the combination of your recent illness and the body's altered immune response could lead to a delayed reaction.

Given your history of egg allergy and the recent onset of hives, it is crucial to monitor your symptoms closely. If the hives persist or worsen, it would be advisable to consult with an allergist or immunologist. They may recommend allergy testing to determine if there are other allergens at play or if your sensitivity to eggs has changed.

In the meantime, managing your symptoms with antihistamines, as prescribed by your doctor, can help alleviate the discomfort associated with hives. Keeping a diary of your symptoms, including what you eat and any environmental factors, can also provide valuable insights into potential triggers.

Lastly, if you experience any symptoms of anaphylaxis, such as difficulty breathing, swelling of the face or throat, or rapid heartbeat, seek emergency medical attention immediately. Understanding your body's reactions and working with healthcare professionals will help you navigate this challenging situation and improve your quality of life.

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