Adjuvant Therapy Options for Colorectal Cancer Patients - Oncology

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Adjuvant medication


Hello, Dr.
Lai! I recently underwent a colonoscopy, and it was found that there are two flat polyps extending horizontally at the cecum: one measuring approximately 1.5 cm x 0.7 cm and the other in a V-shape measuring about 2 cm x 0.5 cm.
Visually, they are diagnosed as malignant tumors, and the pathology report is still pending.
I have already been scheduled for surgery.
Could you please advise under what circumstances, aside from surgical removal, radiation therapy or chemotherapy would be necessary? Additionally, during this waiting period, is it safe to take any adjunctive medications? I've heard that Sanghuang mushroom and fucoidan have effects in preventing the spread of cancer cells; is this true? If so, should I take Sanghuang mushroom or fucoidan? Thank you for your assistance!

K.K., 60~69 year old female. Ask Date: 2017/04/28

Dr. Lai Yicheng reply Oncology


Dear Ms.
K.K.,
Thank you for your inquiry.
Here are the responses:
1.
All diagnoses should be based on the pathological report from laboratory tests.
If it is not a malignant tumor, polypectomy may suffice.
However, if it is unfortunately malignant, the pathological report from the right colon resection will serve as the basis.
If there is local lymphatic involvement or invasion of the submucosa and mucosa, chemotherapy will be required.
If there is invasion beyond the colonic mucosa into the peritoneum, in addition to chemotherapy, radiation therapy will also be necessary.
2.
Regarding adjunctive medications, there is no research available, so I cannot provide any solid recommendations.
Wishing you all the best.
Sincerely,
Dr.
Lai Yi-Cheng
Department of Radiation Oncology

Reply Date: 2017/04/28

More Info


Understanding adjuvant therapy options for colorectal cancer patients is crucial, especially following the discovery of malignant polyps during a colonoscopy. In your case, where two flat polyps were identified in the cecum, the next steps will depend significantly on the final pathology report after surgical resection.
Adjuvant therapy, which includes chemotherapy and radiation, is typically considered in specific scenarios. For colorectal cancer, the decision to use adjuvant chemotherapy is often based on several factors, including the stage of cancer, the presence of lymph node involvement, and the overall health of the patient. If the cancer is found to be invasive and has spread to nearby lymph nodes, adjuvant chemotherapy is usually recommended to reduce the risk of recurrence.
In your situation, if the pathology report confirms that the polyps are indeed malignant and invasive, and if there is evidence of lymph node involvement, your oncologist may suggest adjuvant chemotherapy. Radiation therapy is less commonly used in colorectal cancer unless the cancer is rectal cancer, where it may be used in conjunction with chemotherapy before surgery (neoadjuvant therapy) or after surgery (adjuvant therapy) to reduce the risk of local recurrence.

Regarding your question about the use of adjunctive supplements like桑黃 (Sang Huang) and褐藻糖膠 (Fucoidan), there is limited scientific evidence to support their efficacy in preventing cancer spread. While some studies suggest that certain natural products may have anti-cancer properties, they should not replace conventional treatment methods. It is essential to discuss any supplements with your healthcare provider before starting them, especially during the waiting period for surgery. They can interact with medications and potentially affect your treatment outcomes.

In the interim, focusing on a balanced diet, staying hydrated, and maintaining a healthy lifestyle can be beneficial. Once the surgery is completed and you receive the pathology results, your healthcare team will provide a tailored treatment plan, which may include adjuvant therapy if indicated.

In summary, the decision for adjuvant therapy will largely depend on the final pathology results post-surgery. If the cancer is confirmed to be invasive and has spread, chemotherapy may be recommended. Always consult with your oncologist regarding any supplements or alternative treatments to ensure they align with your overall treatment plan. Your health and safety should always come first, and your medical team is there to guide you through this process.

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