Schizophrenia: Treatment Challenges and Options for Families - Psychiatry

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Schizophrenia


A family member has been diagnosed with schizophrenia and has been undergoing treatment for over six months.
The medications have been changed frequently, and the dosage has increased.
Currently, they are taking 30 mg of Aripiprazole, 20 mg of Ziprasidone, and one tablet of Quetiapine in the morning and evening, but there has been no improvement; auditory hallucinations and delusions persist.
After researching others' experiences, it seems that no one else is on such high doses.
If this continues, will they need electroconvulsive therapy (ECT)? Are there other medications that can be tried? When I visited the acute care unit, I spoke with patients who had undergone ECT, and they mentioned needing anesthesia, which sounds quite frightening.

Sophia, 30~39 year old female. Ask Date: 2017/05/24

Dr. Zhang Fangrong reply Psychiatry


Dear Sir/Madam,
Thank you for your inquiry.
Based on the medication information you provided, the dosage your family member is taking is indeed high.
It is occasionally observed in clinical practice that patients may have a poor response to medication treatment, leading to gradual adjustments.
Your family member may also have other options.
Firstly, seeking evaluation and treatment from a second physician may yield different results.
Of course, the physician's treatment experience is an important factor.
Additionally, if the treatment goal is to reduce the frequency of hallucinations rather than completely eliminate them, the medication dosage can be slightly lowered.
Regarding electroconvulsive therapy (ECT), when performed under anesthesia, it is very safe and has good efficacy.
There are some side effects, which the physician can further explain.
Wishing you good physical and mental health.
Sincerely,
Dr.
Chang Fang-Rong
Department of Psychiatry

Reply Date: 2017/05/24

More Info


Understanding schizophrenia and its treatment can be a complex and challenging journey for both patients and their families. Schizophrenia is a severe mental disorder characterized by distortions in thinking, perception, emotions, language, and sense of self. Common symptoms include hallucinations, delusions, and disorganized thinking, which can significantly impact daily functioning and quality of life.


Treatment Challenges
1. Medication Management: One of the primary treatments for schizophrenia is antipsychotic medication. However, finding the right medication and dosage can be a trial-and-error process. As you mentioned, your family member has been on multiple medications, including Aripiprazole (安立復), Ziprasidone (津普速), and Lurasidone (速悅), with limited success. It's not uncommon for patients to require adjustments in their medication regimen, and some may need to try several different medications before finding one that effectively manages their symptoms.

2. Side Effects: Antipsychotic medications can have side effects, which may lead to non-compliance or the need for additional medications to manage these side effects. This can complicate treatment further, as the patient may end up on a regimen that includes multiple medications, increasing the risk of interactions and side effects.

3. Stigma and Misunderstanding: Families often face stigma and misunderstanding from society regarding schizophrenia. This can lead to feelings of isolation and frustration, making it essential for families to seek support and education about the disorder.

4. Lack of Immediate Results: It can be disheartening for families when medications do not yield immediate results. Schizophrenia treatment often requires patience, as it may take weeks or even months to see significant improvements.


Treatment Options
1. Medication Adjustments: If the current medications are not effective, it may be worth discussing with the psychiatrist the possibility of trying other antipsychotics or adjusting the dosages. There are several classes of antipsychotic medications, including atypical antipsychotics, which may be more effective for some patients.

2. Psychotherapy: Alongside medication, psychotherapy can be beneficial. Cognitive Behavioral Therapy (CBT) has been shown to help individuals with schizophrenia manage their symptoms and improve their quality of life. Family therapy can also be helpful in addressing the dynamics within the family and providing support.

3. Electroconvulsive Therapy (ECT): ECT is sometimes considered for patients with severe symptoms that do not respond to medication. While it may sound intimidating, ECT is a well-established treatment for severe depression and some cases of schizophrenia. It is performed under anesthesia, and many patients report significant improvements in their symptoms.

4. Supportive Services: Engaging with community resources, such as support groups for both patients and families, can provide emotional support and practical advice. Organizations dedicated to mental health can offer resources and connect families with others who have similar experiences.

5. Lifestyle Changes: Encouraging a healthy lifestyle, including regular exercise, a balanced diet, and good sleep hygiene, can also support overall mental health and potentially improve treatment outcomes.


Conclusion
Navigating the treatment of schizophrenia is undoubtedly challenging, and it is essential to maintain open communication with healthcare providers. If the current treatment plan is not yielding results, do not hesitate to advocate for your family member by discussing alternative options with their psychiatrist. Remember that recovery is a journey, and while it may take time to find the right combination of treatments, there is hope for improvement. Seeking support for yourself and your family can also be a vital part of this process.

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