Upper Eye Pain: Neuropathic Issues and Sleep Impact - Neurology

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Headache, neuralgia


Hello Doctor, the patient is experiencing a dull, aching pain in the upper part of both eyeballs (not the eye sockets) and the area between the eyebrows, which sometimes radiates to the occipital region at the back of the head.
This discomfort persists throughout the day, especially after leaning on the desk or lying down for a nap, with slight improvement in the evening.
The patient also reports insufficient sleep (adequate sleep duration, minimal nighttime awakenings), leading to severe daytime fatigue, and has a history of mild obstructive sleep apnea (OSA) with prior surgery.
Brain MRI and sinus CT scans have been performed, with no issues found by ophthalmology, and neurology reports normal imaging.
The sleep specialist indicated that OSA would not cause these symptoms, and after long-term treatment, psychiatry concluded that the patient does not have depression.
ENT evaluations showed normal imaging but diagnosed chronic hypertrophic rhinitis.
The patient believes the pain is related to "nerve" involvement, suggesting it could be neuropathic pain, which is why no treatment has been initiated.
Various medications, including muscle relaxants, analgesics, migraine medications, antidepressants, and nasal allergy treatments, have been tried without any response.
The patient is seeking clarification on whether there can be neuropathic pain in the upper part of the eyeball and if such nerve involvement could affect sleep and contribute to daytime fatigue.

nobody, 40~49 year old female. Ask Date: 2017/06/02

Dr. Jiang Junyi reply Neurology


Hello, based on your description, cervical myofascial pain should be considered first.
Symptoms may include pain, discomfort, muscle stiffness, or a heavy sensation.
(Your symptoms may be indicative of cervicogenic headache, which involves the sensory nerves near the upper cervical spine (specifically the occipital bone and the first and second cervical vertebrae) and the trigeminal nerve nucleus, leading to symptoms similar to trigeminal neuralgia, such as facial and head sensations, for example, facial numbness.) Symptoms may worsen with changes in weather and can be alleviated with stretching activities, often recurring.
During acute episodes, there may be localized muscle tension, spasms, and restricted movement.
However, some muscle disorders, such as myasthenia gravis, may also cause similar fatigue-like symptoms.
It is advisable to consult a neurologist for further evaluation and treatment.
Wishing you good health and happiness.

Reply Date: 2017/06/02

More Info


Understanding the symptoms you are experiencing, particularly the discomfort in the upper part of your eyes and the associated feelings of fatigue and mental fog, requires a comprehensive approach that considers various potential underlying causes. The pain you describe, which is located in the upper eye area and extends to the back of the head, could indeed be related to neuropathic issues, particularly given the chronic nature of your symptoms and the lack of findings from various medical evaluations.

Firstly, it is essential to recognize that the upper eye region is innervated by branches of the trigeminal nerve, particularly the frontal nerve, which can be involved in neuropathic pain syndromes. Neuropathic pain is characterized by pain that arises from damage to or dysfunction of the nervous system, and it can manifest in various ways, including burning, tingling, or aching sensations. In your case, the dull, aching pain you describe could potentially be a form of neuropathic pain, especially if it is persistent and unresponsive to typical analgesics.

The relationship between sleep disturbances and neuropathic pain is well-documented. Chronic pain can significantly affect sleep quality, leading to insomnia or fragmented sleep patterns. In your situation, even though you report sufficient sleep duration, the quality of that sleep may be compromised due to the discomfort you experience, particularly when lying down. This can lead to a cycle of fatigue, where the pain disrupts sleep, and the resultant lack of restorative sleep exacerbates the perception of pain and overall mental fatigue.

Moreover, your mention of experiencing symptoms that worsen when lying down or after napping suggests a possible connection to postural changes affecting the cervical spine or the surrounding musculature. Conditions such as cervicogenic headaches, which originate from the cervical spine, can present with referred pain to the head and eyes, and they can be exacerbated by certain positions. Muscle tension in the neck and upper back can also contribute to headaches and eye discomfort, particularly if there is a history of poor posture or prolonged periods of sitting, which is common in today’s lifestyle.

Given that you have undergone extensive evaluations, including MRI and CT scans, and have been assessed by various specialists without definitive findings, it may be beneficial to explore a multidisciplinary approach. This could include physical therapy focused on the cervical spine and upper back, which may help alleviate muscle tension and improve overall posture. Additionally, cognitive-behavioral therapy (CBT) could be beneficial in addressing any anxiety or stress that may be contributing to your symptoms, even if depression has been ruled out.

In conclusion, while it is challenging to pinpoint a singular cause for your symptoms, the interplay between neuropathic pain, sleep disturbances, and mental fatigue is significant. It is crucial to continue working with your healthcare providers to explore all potential avenues for treatment, including physical therapy, lifestyle modifications, and possibly alternative pain management strategies. Your symptoms deserve a thorough and empathetic approach, and addressing them holistically may lead to improved quality of life and symptom relief.

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