RT-PCR Results and HIV Concerns After Low-Risk Sexual Activity - Internal Medicine

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It's understandable to feel anxious after a potential exposure to HIV, even if the risk was considered low. Based on the information you've provided, let's break down your concerns regarding the RT-PCR results, your symptoms, and the overall risk of HIV infection.

First, it's important to clarify what RT-PCR (Reverse Transcription Polymerase Chain Reaction) testing is. This test is designed to detect the presence of the HIV virus itself, rather than the antibodies that the body produces in response to the virus. RT-PCR can detect HIV earlier than antibody tests, typically within 10 to 14 days after exposure. However, the accuracy of the test can depend on several factors, including the timing of the test relative to the exposure and the individual's immune response.

In your case, you mentioned that you had a low-risk sexual encounter and subsequently experienced mild symptoms, such as leg weakness. After 10 days, you underwent RT-PCR testing, which returned a negative result. This is a reassuring sign, as it suggests that there was no detectable viral load at that time. It's also worth noting that acute HIV symptoms can vary widely and may not always present immediately after infection. However, the symptoms you described, such as leg weakness and slight fever, are not specific to HIV and could be attributed to a variety of other causes, including anxiety, stress, or even a mild viral infection unrelated to HIV.

Regarding your concern about the timing of the RT-PCR test and the possibility of a false negative, it is indeed rare for a person to have acute HIV infection and test negative on an RT-PCR test, especially if the test is conducted within the appropriate window period. The likelihood of a false negative decreases significantly with proper timing and testing protocols. Given that you had a negative result at 10 days post-exposure, it is unlikely that your symptoms are related to HIV.

As for your body temperature fluctuations, it's important to remember that normal body temperature can vary throughout the day and can be influenced by many factors, including physical activity, stress, and environmental conditions. A rectal temperature of 37.7 to 37.8 degrees Celsius is slightly elevated but not necessarily indicative of a fever, which is typically defined as a temperature above 38 degrees Celsius. The fact that your temperature returned to normal after receiving your test results suggests that anxiety may have played a role in your initial elevation.

You mentioned that you plan to undergo an antibody test at 84 days post-exposure, which is a prudent decision. Antibody tests are generally considered conclusive after this period, and if you test negative, you can be reassured about your HIV status. It's also worth noting that the risk of contracting HIV from oral sex is significantly lower compared to anal or vaginal intercourse, especially if there are no open sores or bleeding involved.

In summary, based on your negative RT-PCR result and the nature of your symptoms, it is unlikely that your leg weakness and slight fever are related to HIV. However, if you continue to experience symptoms or have concerns about your health, it is always best to consult with a healthcare professional who can provide personalized advice and support. Additionally, practicing safe sex, including the use of condoms, is essential in reducing the risk of HIV and other sexually transmitted infections. If you find yourself feeling overwhelmed by anxiety regarding HIV, consider seeking support from a mental health professional who can help you manage these feelings.