the Link Between Lymphocytic Choriomeningitis and STDs - Internal Medicine

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Lymphogranuloma venereum (LGV) and sexually transmitted infections (STIs)?


In patients with Sjögren's syndrome, the occurrence of sexually transmitted infections (STIs) or gastrointestinal diseases can trigger ocular diseases and arthritis.
Since this condition is autoimmune in nature and has associations with STIs, individuals with Sjögren's syndrome may be at a higher risk of contracting STIs compared to the general population.

The treatment of STIs can be more complicated in these patients, particularly for infections like HIV, which affect the immune system.
However, with appropriate medical management, it is possible to control the progression of HIV and maintain a good quality of life.
Regarding the medication used for Sjögren's syndrome, such as Salagen (pilocarpine), there is no evidence to suggest that it would affect HIV test results.
However, the use of immunosuppressive agents can potentially increase the risk of acquiring STIs or HIV due to a compromised immune response.
It is important for patients on such medications to engage in safe practices and have regular screenings for STIs.

Niming, 20~29 year old female. Ask Date: 2017/06/24

Dr. Gao Jiankai reply Internal Medicine


Hello, thank you for your inquiry.
Here are my responses:
1.
Reactive arthritis is related to individual susceptibility, making it easier to develop arthritis following an infection.
Some cases of reactive arthritis are associated with sexually transmitted infections (triggered by urinary tract infections), but this does not mean that these patients are more likely to contract sexually transmitted infections.
2.
Even if reactive arthritis is present alongside HIV, it can still be treated; however, medication management requires more careful consideration, so there is no need for concern.
3.
"Salazopyrin" will not affect test results, so please do not worry.
4.
"Salazopyrin" is an immunosuppressant, which generally lowers immune function.
Therefore, in addition to avoiding unsafe sexual practices, it is also recommended to temporarily discontinue this medication during concurrent infections until the infection is under control, after which it can be resumed.
Sincerely, the Allergy, Immunology, and Rheumatology Department of Changhua Hospital, Ministry of Health and Welfare.
We care about you.

Reply Date: 2017/06/24

More Info


Lymphocytic choriomeningitis (LCMV) is a viral infection that can cause a range of symptoms, including fever, headache, and in some cases, neurological complications. While LCMV itself is not directly linked to sexually transmitted diseases (STDs), the underlying immunological factors and behaviors associated with certain conditions can create a complex interplay between autoimmune diseases, STDs, and overall health.

In the context of reactive arthritis, such as that seen in conditions like Reiter's syndrome (or reactive arthritis), infections—especially those of the urogenital or gastrointestinal tract—can trigger inflammatory responses that affect the joints and eyes. This is particularly relevant for individuals with a predisposition to autoimmune conditions, as their immune systems may react more aggressively to infections.
Regarding the question of whether individuals with conditions like Reiter's syndrome are more susceptible to STDs, it is essential to consider that the risk of contracting STDs is primarily influenced by sexual behavior rather than the presence of autoimmune diseases. However, individuals with compromised immune systems, whether due to autoimmune diseases or medications that suppress immune function (like corticosteroids or other immunosuppressants), may have a reduced ability to fight off infections, including STDs. This does not necessarily mean they are more likely to contract STDs, but if they do, the infections may be more challenging to treat due to their compromised immune response.

When it comes to the treatment of STDs in individuals with autoimmune conditions, the presence of an STD like HIV can complicate management. HIV is an immunodeficiency virus that attacks the immune system, making individuals more susceptible to opportunistic infections and other complications. For someone with both an autoimmune condition and HIV, careful management is crucial. Antiretroviral therapy (ART) can effectively control HIV, allowing individuals to maintain a relatively normal immune function, but the interaction between ART and immunosuppressive medications must be managed carefully by healthcare providers.

As for the medication "Salar" (likely referring to sulfasalazine or a similar drug), it is important to note that immunosuppressive medications can affect the results of certain tests, including those for HIV. However, the primary concern is not the medication itself but rather the underlying immune status of the individual. Immunosuppressive therapy can increase the risk of infections, including STDs, but it does not inherently increase the likelihood of contracting HIV.

In summary, while there is a complex relationship between autoimmune diseases, STDs, and the immune system, the primary factors influencing STD risk remain behavioral. Individuals with autoimmune conditions should be vigilant about safe sexual practices and regular health screenings. If they are diagnosed with an STD, they should work closely with their healthcare providers to manage both their autoimmune condition and any infections effectively. Regular follow-up and open communication with healthcare professionals are key to maintaining health and managing the risks associated with both autoimmune diseases and STDs.

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