RU486: What to Expect After Taking the Medication - Obstetrics and Gynecology

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RU486, also known as Mifepristone, is a medication used for medical abortion, primarily in the early stages of pregnancy. Understanding what to expect after taking RU486 is crucial for anyone considering or undergoing this process.
When you take RU486, it works by blocking the hormone progesterone, which is necessary for maintaining a pregnancy. This leads to the breakdown of the uterine lining and detachment of the embryo. After taking RU486, it is common to experience abdominal pain or cramping, which is a sign that the medication is working. This discomfort can vary in intensity and may be accompanied by bleeding, which typically begins within a few hours to a few days after taking the medication.

In your case, taking six RU486 tablets at once is a standard dosage, and it is not uncommon to experience abdominal pain shortly after ingestion. This pain is usually due to the uterus contracting as it begins to expel its contents. However, if the pain becomes severe or is accompanied by heavy bleeding (soaking through two or more pads in an hour), it is important to seek medical attention immediately.

Regarding your concern about the size of the placenta at two weeks, it is important to note that at this early stage, the embryo and placenta are still quite small. However, RU486 is effective even in early pregnancies, and the medication is designed to facilitate the process of expulsion. After taking RU486, you will typically follow up with a second medication, usually Misoprostol, which induces contractions to help expel the pregnancy tissue.

To determine whether the medical abortion has been successful, you will need to monitor your symptoms. Successful expulsion is often indicated by heavy bleeding and the passage of tissue. It is also recommended to have a follow-up appointment with your healthcare provider about one to two weeks after taking the medication. During this visit, your doctor may perform an ultrasound or a blood test to confirm that the pregnancy has been terminated.

In terms of aftercare, it is essential to take care of your body during this time. Rest is crucial, and you should avoid strenuous activities. It is also advisable to refrain from using tampons or having sexual intercourse until your doctor gives you the green light, usually after your follow-up appointment.
If you experience any concerning symptoms, such as prolonged heavy bleeding, severe pain, fever, or foul-smelling discharge, you should contact your healthcare provider immediately. These could be signs of complications, such as infection or incomplete abortion.

In summary, after taking RU486, it is normal to experience some abdominal pain and bleeding as your body begins the process of expulsion. Monitoring your symptoms and following up with your healthcare provider are essential steps to ensure your health and well-being during this process. Always consult your doctor if you have any concerns or questions about your experience with RU486.