Elevated Liver Enzymes: Causes and Concerns - Gastroenterology and Hepatology

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Elevated liver enzymes indicating inflammation?


Hello, doctor.
I went to the family medicine clinic last week for a blood test, and today the report came back.
My blood sugar, cholesterol, and triglycerides are all normal, but my liver enzymes are elevated.
The family medicine doctor said I have liver inflammation, with an ALT level of 60 (the normal range is 7-42).
Is this considered serious? My previous test results from a year and a half ago were normal.
Over the past year and a half, I have regained weight (I weigh over 100 kg).
Could this be related to obesity? Today, I also had blood tests to check for hepatitis B and an abdominal ultrasound scheduled.
I'm quite worried.
I usually go to bed around midnight and wake up around 5 AM, and I tend to stay up late on weekends.

Miss Chen, 30~39 year old female. Ask Date: 2017/07/19

Dr. Cai Anshun reply Gastroenterology and Hepatology


Hello: An ALT level of 60 (with a standard range of 7-42) indicates a liver condition that is not considered severe.
However, it may be caused by fatty liver or insufficient sleep.
Once the underlying cause is identified, further measures can be taken to improve the situation, which may help lower the liver enzyme levels.
Changhua Hospital cares about your health.
Dr.
Tsai An-Shun.

Reply Date: 2017/07/19

More Info


Elevated liver enzymes, particularly alanine aminotransferase (ALT), can be a cause for concern, as they often indicate liver inflammation or damage. In your case, an ALT level of 60, which exceeds the normal range of 7-42, suggests that there is indeed some degree of liver inflammation. While this elevation is not the most severe, it is essential to understand the potential causes and implications of your condition.

One of the most common causes of elevated liver enzymes is fatty liver disease, which can be associated with obesity. Given that you mentioned a recent weight gain, it is plausible that your liver enzyme elevation could be linked to non-alcoholic fatty liver disease (NAFLD). This condition occurs when excess fat accumulates in the liver, leading to inflammation and potentially progressing to more severe liver damage if not addressed. Lifestyle factors, such as diet and physical activity, play a significant role in the development of NAFLD. Therefore, it would be beneficial to consider dietary changes and increasing physical activity to help manage your weight and improve liver health.

Additionally, your lifestyle habits, including late-night sleeping patterns and lack of adequate rest, may contribute to overall health issues, including liver function. Chronic sleep deprivation can lead to metabolic disturbances, which may exacerbate conditions like fatty liver disease. It is advisable to establish a more regular sleep schedule, aiming for 7-9 hours of sleep per night, to support your overall health and liver function.

You mentioned that you are undergoing tests for hepatitis B and C. This is an important step, as viral hepatitis can also lead to elevated liver enzymes. Hepatitis B, in particular, can cause significant liver inflammation and damage if left untreated. The results of these tests will provide crucial information about whether a viral infection is contributing to your elevated liver enzymes.

In the meantime, it is essential to avoid substances that can further harm your liver, such as alcohol and certain medications that may be hepatotoxic. Maintaining a balanced diet rich in fruits, vegetables, whole grains, and lean proteins while minimizing processed foods and sugars can also support liver health.

If your liver enzymes remain elevated or if you experience symptoms such as jaundice (yellowing of the skin and eyes), abdominal pain, or fatigue, it is crucial to follow up with your healthcare provider. They may recommend further testing, such as imaging studies or a liver biopsy, to assess the extent of liver damage and determine the best course of action.

In summary, while an ALT level of 60 indicates liver inflammation, it is not necessarily indicative of severe liver disease at this stage. Factors such as obesity, lifestyle habits, and potential viral infections should be considered in understanding your liver health. Taking proactive steps to improve your diet, increase physical activity, and manage stress can significantly impact your liver function and overall well-being. Regular follow-ups with your healthcare provider will be essential in monitoring your liver health and addressing any concerns that may arise.

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