When to Stop Medication for Hyperthyroidism: A Patient's Concern - Internal Medicine

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The issue of when to discontinue medication for hyperthyroidism?


Hello, doctor.
This April, I experienced a noticeable increase in heart rate along with other uncomfortable symptoms.
At the beginning of May, I visited a family medicine clinic where blood tests diagnosed me with hyperthyroidism.
I was referred to a large hospital for medication treatment, and underwent ultrasounds of my abdomen and neck.
The doctor said everything looked fine, my electrocardiogram was normal, and although there was swelling in my neck, the doctor assured me it would improve.

In the first month, I took Propylthiouracil (Pencil Tab 50mg), six tablets daily, but I started experiencing itching and rashes.
In the second month, I switched to Carbimazole (Carbizo Tab 10mg), taking two tablets daily, and began to have severe muscle cramps.
After three months of treatment, the doctor said I no longer needed to take antithyroid medication.

During the initial diagnosis, my blood tests showed:
- Liver function: GOT: 52 (normal range 5-40), GPT: 59
- T4: >30.50 (normal range 5.7-10.91), T3: 3.33 (normal range 0.74-1.46)
After one month of medication, my blood tests showed:
- T4: 1.91 (normal range 0.7-1.8), TSH: <0.008 (normal range 0.35-5.5)
- Liver function: GOT: 83 (normal range 0-34), GPT: 170 (normal range 10-49)
After three months of treatment, my blood tests showed:
- T4: 0.35 (normal range 0.7-1.8)
I read online that hyperthyroidism typically requires medication for at least one to two years and should not be discontinued.
Currently, I have no palpitations but still have neck swelling.
Should I really follow the doctor's advice and stop medication completely? I am very worried...
Is it true that I do not need to take medication during the stabilization period?

Ms. Chen, 20~29 year old female. Ask Date: 2017/08/07

Dr. Xie Rongyuan reply Internal Medicine


Hello: It is recommended to visit the endocrinology department for further examination.
If it is subacute thyroiditis, there will be no need for medication once recovery is achieved.
Thank you for your message!

Reply Date: 2017/08/07

More Info


When it comes to managing hyperthyroidism, the decision to stop medication should always be made in consultation with a healthcare provider. Your situation is particularly nuanced, given your history of symptoms, treatment, and laboratory results.

Hyperthyroidism is a condition characterized by an overactive thyroid gland, which produces excess thyroid hormones (T3 and T4). This can lead to symptoms such as rapid heartbeat, weight loss, anxiety, and in some cases, swelling of the neck due to an enlarged thyroid gland (goiter). The treatment for hyperthyroidism often includes antithyroid medications, such as methimazole or carbimazole, which help reduce the production of thyroid hormones.

In your case, you were initially treated with a higher dose of an antithyroid medication, which was later adjusted due to side effects. After three months of treatment, your T4 levels have normalized, which is a positive sign indicating that the medication has been effective in controlling your hyperthyroidism. However, your TSH level remains suppressed, which is common in the early stages of treatment and may take longer to normalize.

The concern you have about stopping medication is valid. Many sources suggest that treatment for hyperthyroidism should continue for at least one to two years, especially in cases where the condition was severe or if there is a risk of relapse. However, your healthcare provider may have assessed your individual situation and determined that your thyroid function has stabilized enough to discontinue medication. This decision is often based on a combination of factors, including:
1. Thyroid Function Tests: Your recent lab results show that your T4 levels have returned to normal. This is a critical indicator that your thyroid hormone production is now within the normal range.

2. Symptoms: The absence of symptoms such as palpitations or anxiety suggests that your hyperthyroidism is under control. If you were still experiencing significant symptoms, your doctor might recommend continuing treatment.

3. Duration of Treatment: While it is common to continue treatment for a longer duration, some patients may achieve remission sooner. Your doctor may believe that your thyroid has stabilized sufficiently to allow for a trial off medication.

4. Monitoring: If you stop medication, your doctor will likely recommend regular follow-up appointments to monitor your thyroid function closely. This is crucial to catch any potential relapse early.

5. Individualized Care: Each patient’s situation is unique. Your doctor’s recommendation is based on their clinical judgment and experience with your specific case.

It is essential to communicate your concerns with your healthcare provider. If you feel uncertain about stopping the medication, express this to them. They can provide further clarification on their reasoning and may suggest a plan for monitoring your thyroid function after discontinuation.
In summary, while it is understandable to be apprehensive about stopping your medication, the decision should ultimately be guided by your healthcare provider's expertise and your individual health status. Regular monitoring and open communication with your doctor will be key to ensuring your continued health and managing any potential recurrence of hyperthyroidism. If you have lingering doubts, seeking a second opinion from another endocrinologist could also provide additional reassurance.

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