Syphilis: Testing, Treatment, and Safe Practices - Urology

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Questions about syphilis?


Hello doctor, three years ago I was diagnosed with syphilis and received treatment, but I did not follow up afterward.
I haven't experienced any symptoms in the past couple of years.
Recently, I started dating a boyfriend who does not have any sexually transmitted infections.
He has suggested unprotected sex, but I have not agreed to it.
Therefore, I went to the hospital for testing again, but the results are not yet available.

I would like to ask you, are there two types of tests for syphilis? One tests for the presence of the virus, and the other checks for a positive reaction? I asked a nurse friend of mine, and she said that even if the test result is negative and the treatment was successful, if I have unprotected sex with my boyfriend (who has no STIs), I could still potentially relapse with syphilis and transmit it to others.
But doesn't a negative result indicate that I have been treated successfully and am no longer infectious? Is her understanding incorrect?
Additionally, how can I determine if syphilis has been successfully treated and is no longer infectious? Is it based on a negative test result or the virus's survival rate? If the result is negative, does that mean there is no virus left in my body, and can I have unprotected sex with a safe partner?
Furthermore, if syphilis is being treated effectively, how long does it typically take to be cured before I can have unprotected sex? Also, I experience gum bleeding; if I kiss someone, could the infection be transmitted through blood? Thank you, doctor, and I appreciate your help.

Zhuo, 20~29 year old female. Ask Date: 2017/08/17

Dr. Du Shixi reply Urology


Hello: Syphilis requires regular blood tests, and the VDRL index may rise in some individuals, which could indicate a potential for transmission (though the likelihood is low).
Therefore, you should first confirm whether you have experienced a recurrence.
Additionally, safe sexual practices are recommended.
It is difficult to determine how long it will take to be cured; some individuals may not see an increase in their index, while others may experience a rise upon follow-up and require treatment again.
If you are infectious, contact with blood can pose a risk of transmission, so please be cautious.

Transmission of syphilis occurs through: 1.
Close contact during sexual intercourse and other sexual activities, which is the primary route of transmission.
Direct contact with lesions or secretions from the skin or mucous membranes, bodily fluids, and other secretions (such as semen, blood, and vaginal secretions) is highly infectious.
2.
Blood transmission: This can occur through blood transfusions, sharing needles, and other sharp instruments.
3.
Vertical transmission from mother to child: If appropriate treatment is not received in early pregnancy, the infection can be transmitted to the fetus through the placenta, resulting in congenital syphilis in newborns, which can be severe and may even lead to stillbirth or death.

Reply Date: 2017/08/17

More Info


Understanding syphilis is crucial, especially for individuals who have had a previous diagnosis and treatment. Syphilis is a sexually transmitted infection (STI) caused by the bacterium Treponema pallidum. It can have serious health implications if left untreated, but it is also highly treatable with appropriate medical care.

Firstly, regarding your previous diagnosis and treatment for syphilis three years ago, it is essential to follow up with regular testing to ensure that the infection has been fully resolved. Typically, syphilis testing involves two types of tests: non-treponemal tests (like the RPR or VDRL) and treponemal tests (like the FTA-ABS). Non-treponemal tests measure the presence of antibodies that are produced in response to the infection, while treponemal tests confirm the presence of the bacteria itself.
Your nurse friend’s statement about the possibility of transmitting syphilis even after a negative test result may stem from a misunderstanding. If you have been treated successfully for syphilis and your follow-up tests are negative, it generally indicates that the infection has been cleared from your system, and you are not infectious. However, it is crucial to understand that syphilis can be re-acquired if you are exposed to the bacteria again, regardless of your previous treatment status. Therefore, engaging in unprotected sex with a new partner carries the risk of re-infection if they are exposed to syphilis.

To determine if syphilis has been effectively treated, healthcare providers typically look for a decrease in non-treponemal test titers over time. A significant drop in titers (usually a fourfold decrease) indicates successful treatment. If your tests return to a non-reactive state, it suggests that the infection is no longer present, and you should not pose a risk of transmission to your partner.

Regarding your question about the timeline for treatment, syphilis can often be treated effectively with a single dose of benzathine penicillin G, especially in the early stages. However, if the infection is more advanced (secondary or tertiary syphilis), treatment may require additional doses over a longer period. After treatment, follow-up testing is usually recommended at 6, 12, and 24 months to ensure that the infection has been resolved.

As for your concern about bleeding gums and the potential for transmission through kissing, it is important to note that syphilis is primarily transmitted through direct contact with syphilitic sores, which are typically found in the genital area, anus, or mouth. While the risk of transmission through saliva is low, if there are open sores or bleeding gums, there is a theoretical risk of transmission. It is advisable to avoid intimate contact, including kissing, until you have confirmed that you are free of syphilis and have consulted with your healthcare provider.

In summary, if your recent tests come back negative and you have completed your treatment, you should be in the clear regarding syphilis. However, always practice safe sex, including the use of condoms, to protect both yourself and your partner from STIs. Regular check-ups and open communication with your partner about sexual health are vital components of maintaining a healthy relationship. If you have any further concerns or symptoms, do not hesitate to reach out to your healthcare provider for personalized advice and care.

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