Does Bipolar Medication Increase Liver Burden in Hepatitis B Patients? - Psychiatry

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Does having hepatitis B and taking medication for bipolar disorder increase the burden on the liver?


Hello, a friend has contracted hepatitis B due to a needle stick injury.
The viral load has been tested, and there are no antibodies present.
He also has fatty liver and liver function tests showing levels in the 40s.
Recently, due to family-related stress, he has been diagnosed with bipolar disorder.
The doctor has prescribed medication, but he was previously taking traditional Chinese medicine for liver protection.
Since he is now on Western medication, he should not take Chinese medicine concurrently.
I would like to know if the medication for bipolar disorder will increase the burden on his liver.
What would be the best course of action?

Xiao Bai, 30~39 year old female. Ask Date: 2017/09/21

Dr. Huang Weiqin reply Psychiatry


Dear inquirer,
In principle, patients who are currently taking medication for bipolar disorder should have their blood tested for drug levels and liver function indices every three to six months to assess liver burden and safety.
For specific treatment execution and explanations, your friend can discuss this with their physician.

Reply Date: 2017/09/21

More Info


When considering the impact of bipolar medication on liver function in patients with Hepatitis B, it is crucial to understand the interplay between the medications, the underlying liver condition, and the overall health of the patient. Hepatitis B is a viral infection that can lead to chronic liver disease, and managing this condition alongside mental health issues such as bipolar disorder requires careful coordination between healthcare providers.

Firstly, it is important to note that certain medications used to treat bipolar disorder can have varying effects on liver function. Some mood stabilizers and antipsychotics may be metabolized by the liver, which could potentially increase the burden on this organ, especially in patients with pre-existing liver conditions like Hepatitis B. For instance, medications such as valproate and certain atypical antipsychotics can lead to elevated liver enzymes in some patients. Therefore, it is essential for your friend to have regular liver function tests while on these medications to monitor any potential adverse effects.

In your friend's case, since they have been diagnosed with Hepatitis B and have a history of liver function abnormalities (as indicated by the elevated liver enzymes), it is advisable to consult with both a hepatologist (a liver specialist) and a psychiatrist. This multidisciplinary approach ensures that both the mental health and liver health are being managed effectively. The psychiatrist can consider alternative medications that have a lower risk of hepatotoxicity, while the hepatologist can provide guidance on how to safely manage the Hepatitis B condition alongside psychiatric treatment.

Regarding the use of traditional Chinese medicine (TCM) for liver protection, it is generally recommended to avoid combining TCM with Western medications without professional guidance. Some herbal remedies can interact with prescription medications, potentially leading to increased side effects or reduced efficacy of the treatment. Therefore, if your friend is considering continuing TCM while taking bipolar medication, they should discuss this with their healthcare providers to ensure safety and efficacy.

In terms of decision-making, your friend should prioritize open communication with their healthcare team. They should express their concerns about liver health and the potential impact of bipolar medications. It may be beneficial to explore medications that are known to have a safer profile for patients with liver conditions. Additionally, lifestyle modifications such as maintaining a healthy diet, avoiding alcohol, and managing stress can also support liver health.

Lastly, it is crucial to recognize that untreated mental health conditions can lead to increased stress and potentially worsen overall health, including liver function. Therefore, finding a balance between effective mental health treatment and liver protection is key. Your friend should not hesitate to seek a second opinion if they feel uncertain about their treatment plan, as having a comprehensive and coordinated approach is vital for their overall well-being.

In summary, while bipolar medications can potentially increase liver burden in Hepatitis B patients, careful monitoring and collaboration between healthcare providers can help mitigate risks. Regular liver function tests, open communication with healthcare professionals, and consideration of alternative treatments are essential steps in managing both conditions effectively.

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