Syphilis Testing: Can Early Symptoms Be Detected? - Urology

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Syphilis testing


Hello, doctor: I would like to ask if primary syphilis can be detected through testing once it has manifested, or is it possible to be infected but not yet detectable due to the window period? You previously mentioned that contact with oral lesions and bodily fluids could lead to infection.
Does this refer only to contact with syphilitic lesions, or does it also include saliva?

A-Wen, 30~39 year old female. Ask Date: 2017/10/16

Dr. Du Shixi reply Urology


Hello: Saliva is considered a bodily fluid and secretion.
(Syphilis tests may not yield results for about a month, although there are some exceptions.) Please note that the primary transmission route for syphilis is through sexual contact, and it can also be transmitted through blood transfusions.
If a wound comes into direct contact with the infected patient's semen, blood, vaginal secretions, or other mucosal secretions, bodily fluids, and other excretions, transmission may also occur.

Reply Date: 2017/10/16

More Info


When it comes to syphilis testing, understanding the timing of the infection and the nature of the tests is crucial. Syphilis is caused by the bacterium Treponema pallidum and can present in several stages, with primary syphilis being the first stage characterized by the appearance of a painless sore or ulcer, known as a chancre, at the site of infection. This sore typically appears about three weeks after exposure.

In response to your question about whether primary syphilis can be detected through testing, the answer is that it can be detected, but the timing of the test is important. During the primary stage, the body begins to produce antibodies against the syphilis bacterium. However, it may take some time for these antibodies to reach detectable levels in the blood. Most standard syphilis tests, such as the non-treponemal tests (e.g., RPR or VDRL) and treponemal tests (e.g., FTA-ABS), can typically detect antibodies within 1 to 2 weeks after the appearance of the chancre. Therefore, if you go for testing immediately after the sore appears, there is a possibility that the test may not yet show a positive result due to the window period.

Regarding your question about the transmission of syphilis through contact with bodily fluids, it is important to clarify that syphilis is primarily transmitted through direct contact with a syphilis sore during sexual activity. This includes oral, anal, and vaginal sex. While the bacterium can be present in other bodily fluids, such as saliva, the risk of transmission through saliva alone is considered low. The primary concern is direct contact with an active sore or lesion, which can occur during intimate contact.

If you suspect that you have been exposed to syphilis or are experiencing symptoms, it is advisable to seek testing as soon as possible. If you test negative but still have concerns, follow-up testing may be warranted, especially if you continue to have symptoms or if there was a known exposure. It is also important to communicate openly with your healthcare provider about any symptoms you are experiencing and your potential exposure history, as this will help guide the testing and treatment process.

In summary, while primary syphilis can be detected through testing, the timing of the test is critical. If you have a visible sore, it is advisable to get tested, but be aware that it may take some time for antibodies to become detectable. Direct contact with a syphilis sore poses the highest risk for transmission, while contact with saliva alone is less likely to result in infection. Always consult with a healthcare professional for personalized advice and testing recommendations based on your specific situation.

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