Proteinuria and Glomerular Filtration Concerns in Urology - Urology

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Concerns regarding urinary protein and glomerular filtration?


Hello Dr.
Du, please forgive me for continuously asking questions.
When one has no one to consult and many doubts, it can be quite overwhelming.
I have been troubled by the laboratory test results.
The technician mentioned that there is protein leaking from my glomeruli, and that my creatinine ratio is abnormal, along with an abnormal ANA result, urging me to see a doctor quickly.
When I went to the hospital and showed the report to the doctor, he dismissed it, saying that the bacteria mentioned in the report were due to an external infection.
He then referred me to the hospital's laboratory for a urine test, and after a follow-up, prescribed medication without addressing my concerns.
However, I can't shake off the technician's comment about it potentially affecting my liver and kidneys, which are both areas where I already have issues.
Currently, my urinary system is indeed problematic.
I would like to ask Dr.
Du if my current approach is acceptable: to finish the medication I'm on, go for a follow-up, and then assess the recovery results.
If everything is fine, I would wait six months before returning to the initial hospital for further monitoring.
However, if my condition does not improve, I would then see a rheumatologist to investigate whether the abnormal ANA is the cause.
I am quite afraid of going to the hospital and facing all these situations alone.
I appreciate your patience in reading my concerns.
Thank you.

Er Mao, 50~59 year old female. Ask Date: 2017/11/09

Dr. Du Shixi reply Urology


Hello: If possible, find a hospital and a physician for regular follow-ups (preferably a larger hospital with comprehensive specialties).
Running around to different places is not very helpful, and carrying your medical records back and forth can be cumbersome.
In the future, you can go to that location for follow-ups.
If after your visit the physician recommends that you see a specialist in immunology or rheumatology, you can go ahead and do that (they will provide other recommendations if necessary).
If no referrals are made, they will continue to monitor your condition.
Wishing you good health.

Reply Date: 2017/11/09

More Info


Understanding proteinuria and glomerular filtration concerns is crucial for maintaining kidney health and addressing potential underlying conditions. Your concerns about the presence of protein in your urine, abnormal creatinine levels, and the implications of an abnormal ANA (antinuclear antibody) test are valid and warrant careful consideration.


Proteinuria: What It Means
Proteinuria, or the presence of excess protein in the urine, can be an indicator of kidney dysfunction. Normally, the kidneys filter blood, allowing small molecules and water to pass through while retaining larger proteins. When the glomeruli (the filtering units of the kidneys) are damaged, proteins can leak into the urine. This condition can arise from various causes, including diabetes, hypertension, infections, and autoimmune diseases.


Glomerular Filtration Rate (GFR)
The glomerular filtration rate (GFR) is a critical measure of kidney function. It estimates how well your kidneys are filtering waste from the blood. A normal GFR is typically above 90 mL/min/1.73 m². If your GFR is lower, it may indicate kidney impairment. It's essential to monitor this value alongside protein levels to assess kidney health comprehensively.


The Role of Creatinine
Creatinine is a waste product generated from muscle metabolism, and its levels in the blood can indicate how well the kidneys are functioning. Elevated creatinine levels may suggest that the kidneys are not filtering waste effectively. If your creatinine levels are abnormal, it is essential to investigate further to determine the underlying cause.


ANA and Autoimmune Concerns
The presence of an abnormal ANA test can indicate autoimmune disorders, such as lupus or rheumatoid arthritis, which can affect multiple organs, including the kidneys. If your ANA is abnormal, it may be worthwhile to consult a rheumatologist or an immunologist to explore potential autoimmune conditions that could be contributing to your symptoms.


Next Steps in Management
1. Continue Current Medications: It is advisable to complete your current medication regimen as prescribed by your doctor. This will help in managing any immediate symptoms and provide a clearer picture of your condition during follow-up visits.

2. Follow-Up Appointments: Schedule a follow-up appointment with your healthcare provider to discuss your symptoms, test results, and any concerns you may have. It is essential to communicate openly with your doctor about your worries and the impact of your symptoms on your daily life.

3. Further Testing: If your symptoms persist or worsen, consider asking for additional tests, including a repeat urinalysis, kidney ultrasound, or even a referral to a nephrologist for specialized care. They can provide a more in-depth evaluation of your kidney function and any potential underlying issues.

4. Lifestyle Modifications: In the meantime, focus on maintaining a healthy lifestyle. This includes staying hydrated, following a balanced diet low in sodium and protein, managing blood pressure, and avoiding substances that can harm the kidneys, such as excessive alcohol and nonsteroidal anti-inflammatory drugs (NSAIDs).

5. Mental Health Considerations: It’s understandable to feel anxious when facing health concerns. Consider seeking support from friends, family, or mental health professionals to help manage stress and anxiety related to your health.


Conclusion
Your approach to managing your health by completing your current medications and planning for follow-up care is prudent. Monitoring your symptoms and test results will be crucial in determining the next steps. If you experience any new or worsening symptoms, do not hesitate to seek medical attention sooner. Remember, proactive management and open communication with your healthcare team are key to navigating your health concerns effectively.

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