Premature Ovarian Failure: Treatment Options and Concerns - Obstetrics and Gynecology

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Congenital Ovarian Insufficiency


Hello doctor, I have had irregular menstruation since about six months after my first period, and I haven't had a period since I was around 14 years old.
When I was 16, I saw a doctor who diagnosed me with premature ovarian failure and started me on Divina.
I would like to know if there is a chance for my menstrual cycle to return to normal.
Additionally, I have switched doctors and started taking Estromon 0.625 mg, two tablets a day, and from the 15th day, I began taking Provera 10 mg, one tablet daily for a total of 24 days.
Which of these two medications would you recommend? The doctor mentioned that Divina has a low dose and does not have contraceptive effects; does the combination of Estromon and Provera have contraceptive effects? Thank you.

Ka Ka, 20~29 year old female. Ask Date: 2017/11/17

Dr. Lin Manying reply Obstetrics and Gynecology


Dear Ms.
Ka Ka,
1.
It is recommended that you recheck for Premature Ovarian Failure (POF), as the chances of recovery from POF are extremely low.
2.
Both medications (Divina or Estromon 0.625mg for 24 days + Provera 10mg for 12 days) have the same effect.
3.
Neither of these options provides contraceptive effects; however, if POF is confirmed, the chances of pregnancy are extremely low, and contraception is not a consideration in the treatment.
The Hualien Hospital of the Ministry of Health and Welfare cares about your health.

Reply Date: 2017/11/17

More Info


Premature ovarian failure (POF), also known as primary ovarian insufficiency, is a condition where the ovaries cease to function normally before the age of 40. This can lead to irregular or absent menstrual cycles, infertility, and symptoms associated with menopause, such as hot flashes and mood swings. Understanding your treatment options and concerns is crucial for managing this condition effectively.

First, regarding your question about the possibility of restoring normal ovarian function, it is important to note that while some women with POF may experience spontaneous recovery of ovarian function, this is relatively rare. The likelihood of restoring normal ovarian function largely depends on the underlying cause of the ovarian failure. In some cases, hormonal treatments can help manage symptoms and regulate menstrual cycles, but they may not necessarily restore fertility.

You mentioned that you have been prescribed Divina and Estromon, along with Provera. Divina is a combination of estrogen and progestin, which is often used for hormone replacement therapy (HRT) to alleviate menopausal symptoms. Estromon, which contains conjugated estrogens, is also used for HRT. The addition of Provera, a progestin, helps to protect the endometrium (the lining of the uterus) from hyperplasia, which can occur with estrogen therapy alone.

In terms of which medication is more effective, it often depends on individual response and specific symptoms. Both medications can help manage symptoms of estrogen deficiency, but they serve slightly different purposes. Divina may be more beneficial for those who also need progestin for endometrial protection, while Estromon can be effective for estrogen replacement. It is essential to have a thorough discussion with your healthcare provider about the benefits and potential side effects of each medication to determine which is best for you.

Regarding the contraceptive effects of Estromon and Provera, it is important to understand that while progestins can have contraceptive effects, the primary purpose of your current regimen is likely to manage symptoms of POF rather than to prevent pregnancy. However, if you are not actively trying to conceive, it is advisable to discuss contraceptive options with your doctor, as they can provide guidance based on your specific situation.

In terms of fertility, if you are considering pregnancy, it is crucial to consult with a fertility specialist. They can evaluate your ovarian reserve and discuss options such as in vitro fertilization (IVF) using donor eggs, as this may be a viable path for women with POF who wish to conceive. Additionally, some women may benefit from treatments aimed at stimulating ovarian function, although the success rates can vary significantly.

Lastly, it is essential to monitor your emotional and psychological well-being throughout this process. Dealing with POF and the associated challenges can be emotionally taxing, and seeking support from mental health professionals or support groups can be beneficial.

In summary, while there may be limited chances of restoring normal ovarian function in cases of premature ovarian failure, hormone replacement therapy can help manage symptoms. The choice between Divina and Estromon with Provera should be made in consultation with your healthcare provider, considering your specific needs and health status. If pregnancy is a goal, exploring fertility options with a specialist is crucial. Remember, you are not alone in this journey, and there are resources and support available to help you navigate through these challenges.

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